Christophe Marchal

TL;DR: Fanconi anemia complementation group C (FANCC) protein interacts with Parkin, is required in vitro and in vivo for clearance of damaged mitochondria, and decreases mitochondrial reactive oxygen species (ROS) production and inflammasome activation as discussed by the authors.

TL;DR: Fanconi anemia (FA) is a rare inherited disorder clinically characterized by congenital malformations, progressive bone marrow failure and cancer susceptibility as mentioned in this paper, which is associated with hypersensitivity to DNA-crosslinking genotoxins.

TL;DR: It is found that FA signaling is essential for the spindle assembly checkpoint and is therefore required for high-fidelity chromosome segregation and prevention of aneuploidy and the essential role of the FA pathway in mitosis offers a mechanistic explanation for the aneuPLoidsy and malignant transformation known to occur after disruption of FA signaling.

TL;DR: It is demonstrated that Mdm2 holds promise as a therapeutic target in combination with conventional therapy and may lead to new clinical therapies for TNBC, and an intermittent dosing schedule of combined carboplatin and Nutlin-3a was investigated.

TL;DR: Diminished Rac2 expression in cord blood neutrophils may contribute to the defects observed in cord water neutrophil function, and this work postulated that newborn neutrophiles may be deficient in Rac2.