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Ellen Honisch
Researcher at University of Düsseldorf
Publications - 26
Citations - 2040
Ellen Honisch is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Breast cancer & Circulating tumor cell. The author has an hindex of 16, co-authored 22 publications receiving 1686 citations.
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Journal ArticleDOI
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
Alfons Meindl,Heide Hellebrand,Constanze Wiek,Verena Erven,Barbara Wappenschmidt,Dieter Niederacher,Marcel Freund,Peter Lichtner,Linda Hartmann,Heiner Schaal,Juliane Ramser,Ellen Honisch,Christian Kubisch,Hans Erich Wichmann,Karin Kast,Helmut Deissler,Christoph Engel,Bertram Müller-Myhsok,Kornelia Neveling,Marion Kiechle,Christopher G. Mathew,Detlev Schindler,Rita K. Schmutzler,Helmut Hanenberg,Helmut Hanenberg +24 more
TL;DR: In index cases from 1,100 German families with gynecological malignancies, the first unambiguous evidence of highly penetrant mutations associated with human cancer in a RAD51 paralog is provided and support the 'common disease, rare allele' hypothesis.
Journal ArticleDOI
Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations
Timothy R. Rebbeck,Tara M. Friebel,Eitan Friedman,Ute Hamann,Dezheng Huo,Ava Kwong,Edith Olah,Olufunmilayo I. Olopade,Angela R. Solano,Soo-Hwang Teo,Mads Thomassen,Jeffrey N. Weitzel,Tsun Leung Chan,Fergus J. Couch,David E. Goldgar,Torben A Kruse,Edenir Inêz Palmero,Sue K. Park,Sue K. Park,Diana Torres,Diana Torres,Elizabeth J. van Rensburg,Lesley McGuffog,Michael T. Parsons,Goska Leslie,Cora M. Aalfs,Julio Abugattas,Julian Adlard,Simona Agata,Kristiina Aittomäki,Lesley Andrews,Irene L. Andrulis,Irene L. Andrulis,Adalgeir Arason,Norbert Arnold,Banu Arun,Ella Asseryanis,Leo Auerbach,Jacopo Azzollini,Judith Balmaña,Monica Barile,Rosa B. Barkardottir,Daniel Barrowdale,Javier Benitez,Andreas Berger,Raanan Berger,Amie Blanco,Kathleen R. Blazer,Marinus J. Blok,Valérie Bonadona,Bernardo Bonanni,Angela R. Bradbury,Carole Brewer,Bruno Buecher,Saundra S. Buys,Trinidad Caldés,Almuth Caliebe,Maria A. Caligo,Ian G. Campbell,Sandrine M. Caputo,Jocelyne Chiquette,Wendy K. Chung,Kathleen Claes,J. Margriet Collée,Jackie Cook,Rosemarie Davidson,Miguel de la Hoya,Kim De Leeneer,Antoine De Pauw,Capucine Delnatte,Orland Diez,Yuan Chun Ding,Nina Ditsch,Susan M. Domchek,Cecilia M. Dorfling,Carolina Velázquez,Bernd Dworniczak,Jacqueline Eason,Douglas F. Easton,Ros Eeles,Hans Ehrencrona,Bent Ejlertsen,Embrace,Christoph Engel,Stefanie Engert,D. Gareth Evans,Laurence Faivre,Lídia Feliubadaló,Sandra Fert Ferrer,Lenka Foretova,Jeffrey M. Fowler,Debra Frost,Henrique de Campos Reis Galvão,Patricia A. Ganz,Judy Garber,Marion Gauthier-Villars,Andrea Gehrig,Anne-Marie Gerdes,Paul Gesta,Giuseppe Giannini,Sophie Giraud,Gord Glendon,Andrew K. Godwin,Mark H. Greene,Jacek Gronwald,Angelica M. Gutierrez-Barrera,Eric Hahnen,Jan Hauke,Hebon,Alex Henderson,Julia Hentschel,Frans B. L. Hogervorst,Ellen Honisch,Evgeny N. Imyanitov,Claudine Isaacs,Louise Izatt,Angel Izquierdo,Anna Jakubowska,Paul A. James,Ramunas Janavicius,Uffe Birk Jensen,Esther M. John,Esther M. John,Joseph Vijai,Katarzyna Kaczmarek,Beth Y. Karlan,Karin Kast,kConFab Investigators,Sung-Won Kim,Irene Konstantopoulou,Jacob Korach,Yael Laitman,Adriana Lasa,Christine Lasset,Conxi Lázaro,Annette Lee,Min Hyuk Lee,Jenny Lester,Fabienne Lesueur,Annelie Liljegren,Noralane M. Lindor,Michel Longy,Jennifer T. Loud,Karen H. Lu,Jan Lubinski,Eva Machackova,Siranoush Manoukian,Véronique Mari,Cristina Martínez-Bouzas,Zoltan Matrai,Noura Mebirouk,Hanne Meijers-Heijboer,Alfons Meindl,Arjen R. Mensenkamp,Ugnius Mickys,Austin Miller,Marco Montagna,Kirsten B. Moysich,Anna Marie Mulligan,Jacob Musinsky,Susan L. Neuhausen,Heli Nevanlinna,Joanne Ngeow,Huu Phuc Nguyen,Dieter Niederacher,Henriette Roed Nielsen,Finn Cilius Nielsen,Robert L. Nussbaum,Kenneth Offit,Anna Öfverholm,Kai-ren Ong,Ana Osorio,Laura Papi,János Papp,Barbara Pasini,Inge Søkilde Pedersen,Ana Peixoto,Nina Peruga,Paolo Peterlongo,Esther Pohl,Nisha Pradhan,Karolina Prajzendanc,Fabienne Prieur,Pascal Pujol,Paolo Radice,Susan J. Ramus,Susan J. Ramus,Johanna Rantala,Muhammad Usman Rashid,Kerstin Rhiem,Mark E. Robson,Gustavo C. Rodriguez,Mark T. Rogers,Vilius Rudaitis,Ane Y. Schmidt,Rita K. Schmutzler,Leigha Senter,Payal D. Shah,Priyanka Sharma,Lucy Side,Jacques Simard,Christian F. Singer,Anne-Bine Skytte,Thomas P. Slavin,Katie Snape,Hagay Sobol,Melissa C. Southey,Linda Steele,Doris Steinemann,Grzegorz Sukiennicki,Christian Sutter,Csilla Szabo,Yen Y. Tan,Manuel R. Teixeira,Mary Beth Terry,Alex Teulé,Abigail Thomas,Darcy L. Thull,Marc Tischkowitz,Silvia Tognazzo,Amanda E. Toland,Sabine Topka,Alison H. Trainer,Nadine Tung,Christi J. van Asperen,Annemieke H. van der Hout,Lizet E. van der Kolk,Rob B. van der Luijt,Mattias Van Heetvelde,Liliana Varesco,Raymonda Varon-Mateeva,Ana Vega,Cynthia Villarreal-Garza,Anna von Wachenfeldt,Lisa Walker,Shan Wang-Gohrke,Barbara Wappenschmidt,Bernhard H. F. Weber,Drakoulis Yannoukakos,Sook-Yee Yoon,Cristina Zanzottera,Jamal Zidan,Kristin K. Zorn,Christina G. Selkirk,Peter J. Hulick,Georgia Chenevix-Trench,Amanda B. Spurdle,Antonis C. Antoniou,Katherine L. Nathanson +248 more
TL;DR: In addition to known founder mutations, mutations of relatively high frequency were identified in specific racial/ethnic or geographic groups that may reflect founder mutations and which could be used in targeted (panel) first pass genotyping for specific populations.
Journal ArticleDOI
Diagnostic leukapheresis enables reliable detection of circulating tumor cells of nonmetastatic cancer patients
Johannes C. Fischer,Dieter Niederacher,Stefan A. Topp,Ellen Honisch,S. Schumacher,Norma Schmitz,Luisa Zacarias Föhrding,C. Vay,Imke Hoffmann,N Kasprowicz,Philip Hepp,Svjetlana Mohrmann,Ulrike Nitz,Antje Stresemann,Thomas Krahn,Tanja Henze,Evelyn Griebsch,Katharina Raba,Jutta Rox,Folker Wenzel,Christoph Sproll,Wolfgang Janni,Tanja Fehm,Christoph Klein,Wolfram T. Knoefel,Nikolas H. Stoecklein +25 more
TL;DR: Diagnostic leukapheresis is a clinically safe method that enabled a reliable detection of CTCs at high frequency even in nonmetastatic cancer patients, and might facilitate the routine clinical use of C TCs as in the sense of a liquid biopsy.
Journal ArticleDOI
Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells
Rui Neves,Christina Scheel,Sandra Weinhold,Ellen Honisch,Katharina M. Iwaniuk,Hans-Ingo Trompeter,Dieter Niederacher,Peter Wernet,Simeon Santourlidis,Markus Uhrberg +9 more
TL;DR: This study demonstrates that expression of the miR-200c/141 cluster is regulated by DNA methylation, suggesting epigenetic regulation of this miRNA locus in aggressive breast cancer cell lines as well as untransformed mammary epithelial cells.
Journal ArticleDOI
Gene panel testing of 5589 BRCA1/2-negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer.
Jan Hauke,Judit Horvath,Eva Groß,Andrea Gehrig,Ellen Honisch,Karl Hackmann,Gunnar Schmidt,Norbert Arnold,Ulrike Faust,Christian Sutter,Julia Hentschel,Shan Wang-Gohrke,Mateja Smogavec,Bernhard H. F. Weber,Nana Weber-Lassalle,Konstantin Weber-Lassalle,Julika Borde,Corinna Ernst,Janine Altmüller,Alexander E Volk,Holger Thiele,Verena Hübbel,Peter Nürnberg,Katharina Keupp,Beatrix Versmold,Esther Pohl,Christian Kubisch,Sabine Grill,Victoria G. Paul,N Herold,Nadine Lichey,Kerstin Rhiem,Nina Ditsch,Christian Ruckert,Barbara Wappenschmidt,Bernd Auber,Andreas Rump,Dieter Niederacher,Thomas Haaf,Juliane Ramser,Bernd Dworniczak,Christoph Engel,Alfons Meindl,Rita K. Schmutzler,Eric Hahnen +44 more
TL;DR: A significant association of deleterious variants in the CHEK2, PALB2, and TP53 genes with bilateral BC is demonstrated and predicted damaging rare missense variants were significantly more prevalent in CHEk2 and TP 53 in BC index patients.