C
Christopher A. Smith
Researcher at University of Birmingham
Publications - 37
Citations - 6877
Christopher A. Smith is an academic researcher from University of Birmingham. The author has contributed to research in topics: Plasmid & Gene. The author has an hindex of 24, co-authored 34 publications receiving 6825 citations. Previous affiliations of Christopher A. Smith include Keele University.
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Journal ArticleDOI
Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures.
TL;DR: It is shown that engaging the CD3/TCR complex of immature mouse thymocytes with anti-CD3 antibodies produces DNA degradation and cell death through the endogenous pathway of apoptosis.
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Mechanism of antigen-driven selection in germinal centres.
Yong-Jun Liu,Douglas E. Joshua,Gwyn T. Williams,Christopher A. Smith,John Gordon,I. C. M. Maclennan +5 more
TL;DR: It is found that, on culture, centrocytes isolated from human tonsil kill themselves within a few hours by apoptosis, not a feature of other tonsillar B cells.
Journal ArticleDOI
Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
TL;DR: It is shown that the death of haemopoietic precursor cells on withdrawal of the relevant CSF is due to active cell death5, or apoptosis, indicating that CSFs promote cell survival by suppression of the process of apoptosis.
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Molecular regulation of apoptosis: Genetic controls on cell death
TL;DR: It is now widely accepted that apoptosis is a genedirected process and can be seen, alongside more familiar gene-directed processes like differentiation, as part of the repertoire available to the cell to respond to external and internal stimuli.
Journal ArticleDOI
Apoptosis: Molecular Regulation of Cell Death
Annette J. Hale,Christopher A. Smith,Leslie C. Sutherland,Victoria E. A. Stoneman,Vanessa L. Longthorne,Aedín C. Culhane,Gwyn T. Williams +6 more
TL;DR: Although apoptosis is now accepted as a critical element in the repertoire of potential cellular responses, the picture of the intra-cellular processes involved is probably still incomplete, not just in its details, but also in the basic outline of the process as a whole.