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Christopher Corpe
Researcher at King's College London
Publications - 50
Citations - 4245
Christopher Corpe is an academic researcher from King's College London. The author has contributed to research in topics: Glucose transporter & Medicine. The author has an hindex of 17, co-authored 42 publications receiving 3694 citations. Previous affiliations of Christopher Corpe include University of Illinois at Chicago & Pennsylvania State University.
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Journal ArticleDOI
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Sebastian J. Padayatty,Arie Katz,Yaohui Wang,Peter Eck,Oran Kwon,Je-Hyuk Lee,Shenglin Chen,Christopher Corpe,Anand Dutta,Sudhir K. Dutta,Mark Levine +10 more
TL;DR: Dose concentration studies of vitamin C in healthy people showed a sigmoidal relationship between oral dose and plasma and tissue vitamin C concentrations, so optimal dosing is critical to intervention studies using vitamin C.
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Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
Qi Chen,Michael Graham Espey,Murali C. Krishna,James B. Mitchell,Christopher Corpe,Garry R. Buettner,Emily Shacter,Mark Levine +7 more
TL;DR: Human pharmacokinetics data indicate that ascorbate at concentrations achieved only by i.v. administration may be a pro-drug for formation of H(2)O(2), and that blood can be a delivery system of the pro- drug to tissues.
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Inhibition of the intestinal glucose transporter GLUT2 by flavonoids
Oran Kwon,Peter Eck,Shenglin Chen,Christopher Corpe,Je-Hyuk Lee,Michael J. Kruhlak,Mark Levine +6 more
TL;DR: Flavonols show promise as new pharmacologic agents in the obesity epidemic because the flavonoid quercetin might act as a potent luminal inhibitor of sugar absorption independent of its own transport.
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Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice
Christopher Corpe,Hongbin Tu,Peter Eck,Jin Wang,Robert Faulhaber-Walter,Jurgen Schnermann,Sam Margolis,Sebastian J. Padayatty,He Sun,Yaohui Wang,Robert L. Nussbaum,Michael Graham Espey,Mark Levine +12 more
TL;DR: Findings indicate a key role for Slc23a1 in renal ascorbate absorption and perinatal survival and reveal regulation of vitamin C biosynthesis in mice.
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The regulation of GLUT5 and GLUT2 activity in the adaptation of intestinal brush-border fructose transport in diabetes
Christopher Corpe,Muna M. Basaleh,Julie Affleck,Gwyn W. Gould,Thomas J. Jess,George L. Kellett +5 more
TL;DR: Differences in stereospecificity between GLUT2 and GLUT5 were used to show that both transporters contributed to the overall enhancement of D-fructose transport measured in brush-border membrane vesicles and in vitro isolated loops from diabetic rats, however, overall D- fructose uptake in vivo was diminished.