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Christopher D. Hein
Researcher at University of Nebraska Medical Center
Publications - 3
Citations - 772
Christopher D. Hein is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Click chemistry. The author has an hindex of 3, co-authored 3 publications receiving 686 citations.
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Journal ArticleDOI
Click Chemistry, A Powerful Tool for Pharmaceutical Sciences
TL;DR: Important aspects of the Huisgen cycloaddition will be reviewed, along with some of its many pharmaceutical applications, including bioconjugation, nanoparticle surface modification, and pharmaceutical-related polymer chemistry will all be covered.
Journal ArticleDOI
Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)
Yuxiang Dong,Xiaofang Wang,Sriraghavan Kamaraj,Vivek J. Bulbule,Francis C. K. Chiu,Jacques Chollet,Jacques Chollet,Manickam Dhanasekaran,Christopher D. Hein,Petros Papastogiannidis,Petros Papastogiannidis,Julia Morizzi,David M. Shackleford,Helena Barker,Eileen Ryan,Christian Scheurer,Christian Scheurer,Yuanqing Tang,Qingjie Zhao,Lin Zhou,Karen L. White,Heinrich Urwyler,William N. Charman,Hugues Matile,Sergio Wittlin,Sergio Wittlin,Susan A. Charman,Jonathan L. Vennerstrom +27 more
TL;DR: The high curative efficacy of these ozonides was most often associated with high and prolonged plasma exposure, but exposure on its own did not explain the presence or absence of eitherCurative efficacy or in vivo toxicity.
Journal ArticleDOI
The Synthesis of a Multiblock Osteotropic Polyrotaxane by Copper(I)‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition
TL;DR: The design and synthesis of a novel bone-targeting polyrotaxane delivery system that utilizes alendronate (ALN) as targeting moiety is presented and the osteotropicity of the delivery system was confirmed in vivo.