Y
Yuxiang Dong
Researcher at University of Nebraska Medical Center
Publications - 65
Citations - 3385
Yuxiang Dong is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Artemisinin & Tetraoxanes. The author has an hindex of 29, co-authored 62 publications receiving 3095 citations. Previous affiliations of Yuxiang Dong include University of Nebraska–Lincoln.
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Journal ArticleDOI
Identification of an antimalarial synthetic trioxolane drug development candidate.
Jonathan L. Vennerstrom,Sarah Arbe-Barnes,Reto Brun,Susan A. Charman,Francis C. K. Chiu,Jacques Chollet,Yuxiang Dong,Arnulf Dorn,Daniel Hunziker,Hugues Matile,Kylie Anne McIntosh,Maniyan Padmanilayam,Josefina Santo Tomas,Christian Scheurer,Bernard Scorneaux,Yuanqing Tang,Heinrich Urwyler,Sergio Wittlin,William N. Charman +18 more
TL;DR: Here it is described how a synthetic peroxide antimalarial drug development candidate was identified in a collaborative drug discovery project.
Journal ArticleDOI
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
Susan A. Charman,Sarah Arbe-Barnes,Ian Bathurst,Reto Brun,Michael Campbell,William N. Charman,Francis C. K. Chiu,Jacques Chollet,J. Carl Craft,Darren J. Creek,Yuxiang Dong,Hugues Matile,Melanie Maurer,Julia Morizzi,Tien Nguyen,Petros Papastogiannidis,Christian Scheurer,David M. Shackleford,Kamaraj Sriraghavan,Lukas Stingelin,Yuanqing Tang,Heinrich Urwyler,Xiaofang Wang,Karen L. White,Sergio Wittlin,Lin Zhou,Jonathan L. Vennerstrom +26 more
TL;DR: The outstanding efficacy and prolonged blood concentrations of OZ439 are the result of a design strategy that stabilizes the intrinsically unstable pharmacophoric peroxide bond, thereby reducing clearance yet maintaining the necessary Fe(II)-reactivity to elicit parasite death.
Journal ArticleDOI
In Vitro and In Vivo Activities of Synthetic Trioxolanes against Major Human Schistosome Species
Shu Hua Xiao,Jennifer Keiser,Jacques Chollet,Jürg Utzinger,Yuxiang Dong,Yvette Endriss,Jonathan L. Vennerstrom,Marcel Tanner +7 more
TL;DR: The results, along with the low toxicity, metabolic stability, and good pharmacokinetic properties of the OZs, indicate the potential for the development of novel broad-spectrum antischistosomal OZ drug candidates.
Journal ArticleDOI
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Yuxiang Dong,Jacques Chollet,Hugues Matile,Susan A. Charman,Francis C. K. Chiu,William N. Charman,Bernard Scorneaux,Heinrich Urwyler,Josefina Santo Tomas,Christian Scheurer,Christopher Snyder,Arnulf Dorn,Xiaofang Wang,Jean M. Karle,Yuanqing Tang,Sergio Wittlin,Reto Brun,Jonathan L. Vennerstrom +17 more
TL;DR: The trioxolanes were substantially less effective in a standard oral suspension formulation compared to a solubilizing formulation and were more active when administered subcutaneously than orally, both of which suggest substantial biopharmaceutical liabilities.
Journal ArticleDOI
Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials
Darren J. Creek,William N. Charman,Francis C. K. Chiu,Richard John Prankerd,Yuxiang Dong,Jonathan L. Vennerstrom,Susan A. Charman +6 more
TL;DR: Under standardized reaction conditions, a correlation was found between the extent of hemeAlkylation and in vitro antimalarial activity, suggesting that heme alkylation may be related to the mechanism of action for these trioxolanes.