Christopher D. J. Sinclair

TL;DR: In pathologically distinct neuromuscular disorders, the comparative responsiveness of MRI outcome measures over 1 year, the validity ofMRI outcome measures by cross-sectional correlation against functionally relevant clinical measures, and the sensitivity of specific MRI indices to early muscle water changes before intramuscular fat accumulation beyond the healthy control range are determined.

TL;DR: Quantitative muscle MRI, using the Dixon technique, could be used as an important longitudinal outcome measure to assess muscle pathology and monitor therapeutic efficacy in patients with LGMD2I.

TL;DR: The importance of the outcome measures is considered, the considerations required to make robust measurements and appropriate quality assurance measures are discussed, and the existing literature for cross-sectional and longitudinal cohort studies using these methods in muscular dystrophy is drawn together.

TL;DR: MRI is non-invasive, objective and does not rely on patient effort compared to clinical and physical measures that are currently employed and it is demonstrated that the quantitative Dixon technique is an objective quantitative marker of disease.

TL;DR: In this paper, the authors present a useful seminar for readers who want to gain knowledge of the advancements in the MRN pulse sequences currently used in clinical practice as well as learn about the other techniques on the horizon aimed at better depiction of nerve anatomy, pathology, and potential noninvasive evaluation of nerve degeneration or regeneration.