C
Christopher F Mugler
Researcher at University of California, Berkeley
Publications - 12
Citations - 662
Christopher F Mugler is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: DEAD box & Nuclear pore. The author has an hindex of 7, co-authored 12 publications receiving 451 citations. Previous affiliations of Christopher F Mugler include University of California, Santa Barbara & ETH Zurich.
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Journal ArticleDOI
Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability.
TL;DR: Non-invasive transcriptome-wide mRNA production and stability measurements with selective and acute perturbations are combined to demonstrate that mRNA degradation is tightly coupled to the regulation of translation, and that a competition between translation initiation and mRNA decay is the major determinant of mRNA stability in yeast.
Journal ArticleDOI
ATPase activity of the DEAD-box protein Dhh1 controls processing body formation
Christopher F Mugler,Maria Hondele,Stephanie Heinrich,Ruchika Sachdev,Pascal Vallotton,Adriana Y Koek,Leon Y. Chan,Karsten Weis +7 more
TL;DR: It is shown that in budding yeast, mutations in the DEAD-box ATPase Dhh1 that prevent ATP hydrolysis, or that affect the interaction between DHH1 and Not1, the central scaffold of the CCR4-NOT complex and an activator of the Dhh2 ATPase, prevent PB disassembly in vivo.
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Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate
Ze Cheng,Christopher F Mugler,Abdurrahman Keskin,Stefanie Hodapp,Leon Y. Chan,Karsten Weis,Philipp Mertins,Aviv Regev,Marko Jovanovic,Gloria A. Brar +9 more
TL;DR: Two distinct signatures of protein synthesis suggest intriguing and currently mysterious differences in the cellular consequences of deficiency for small and large ribosomal subunits.
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Natively Unfolded FG Repeats Stabilize the Structure of the Nuclear Pore Complex
Evgeny Onischenko,Jeffrey H Tang,Kasper R. Andersen,Kevin E. Knockenhauer,Pascal Vallotton,Carina Patrizia Derrer,Annemarie Kralt,Christopher F Mugler,Leon Y. Chan,Thomas U. Schwartz,Karsten Weis +10 more
TL;DR: The results reveal a previously unanticipated structural role for natively unfolded GLFG repeats as Velcro to link NPC subcomplexes and thus add a new layer of connections to current models of the NPC architecture.
Journal ArticleDOI
Pat1 promotes processing body assembly by enhancing the phase separation of the DEAD-box ATPase Dhh1 and RNA.
Ruchika Sachdev,Maria Hondele,Miriam Linsenmeier,Pascal Vallotton,Christopher F Mugler,Christopher F Mugler,Paolo Arosio,Karsten Weis +7 more
TL;DR: It is shown that the PB component Pat1 antagonizes Not1 and promotes PB assembly via its direct interaction with Dhh1, thereby aiding the assembly of large multivalent mRNP granules that are PBs.