Christopher Harvey

TL;DR: These antibodies inhibited tumor growth in multiple fully immunocompetent mouse models and reduced human melanoma metastases in a humanized mouse model and reactivates antitumor immunity.

TL;DR: This study indicates that adaptive immunity requires an intact FRC network and identifies a subset of FRCs that control B cell homeostasis and follicle identity and indicates a subset that established a favorable niche for B lymphocytes via production of the cytokine BAFF.

TL;DR: These findings provide valuable insight into virus-specific B cell responses in HIV infection and demonstrate that memory B cell abnormalities may contribute to the ineffectiveness of the antibody response in infected individuals.

TL;DR: Analysis of the developmental and transcriptomic signatures of infiltrating myeloid cells from multiple primary tumors found that tumor-associated macrophages and neutrophils exhibited different frequencies, gene expression profiles, and functions dependent on cancer types but not locations.

TL;DR: Jounce is developing a high affinity humanized agonist monoclonal antibody to be tested as both a monotherapy as well as in combination with other T cell checkpoints in solid tumor indications.