P
Paul A. Monach
Researcher at Brigham and Women's Hospital
Publications - 177
Citations - 10629
Paul A. Monach is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Vasculitis & Granulomatosis with polyangiitis. The author has an hindex of 45, co-authored 144 publications receiving 8746 citations. Previous affiliations of Paul A. Monach include University of Pennsylvania & VA Boston Healthcare System.
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Journal ArticleDOI
Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
John H. Stone,Peter A. Merkel,Robert Spiera,Philip Seo,Carol A. Langford,Gary S. Hoffman,Cees G. M. Kallenberg,E. William St. Clair,Anthony M. Turkiewicz,Nadia K. Tchao,Lisa Webber,Linna Ding,Lourdes P. Sejismundo,Kathleen Mieras,David Weitzenkamp,David Ikle,Vicki Seyfert-Margolis,Mark Mueller,Paul Brunetta,Nancy B. Allen,Fernando C. Fervenza,Duvuru Geetha,Karina A. Keogh,Eugene Y. Kissin,Paul A. Monach,Tobias Peikert,Coen A. Stegeman,Steven R. Ytterberg,Ulrich Specks +28 more
TL;DR: Rituximab therapy was not inferior to daily cyclophosphamide treatment for induction of remission in severe ANCA-associated vasculitis and may be superior in relapsing disease.
Journal ArticleDOI
Efficacy of Remission-Induction Regimens for ANCA-associated Vasculitis
Ulrich Specks,Peter A. Merkel,Philip Seo,Robert Spiera,Carol A. Langford,Gary S. Hoffman,Cees G. M. Kallenberg,E. William St. Clair,Barri J. Fessler,Linna Ding,Lisa Viviano,Nadia K. Tchao,Deborah Phippard,Adam Asare,Noha Lim,David Ikle,Brett Jepson,Paul Brunetta,Nancy B. Allen,Fernando C. Fervenza,Duvuru Geetha,Karina A. Keogh,Eugene Y. Kissin,Paul A. Monach,Tobias Peikert,Coen A. Stegeman,Steven R. Ytterberg,Mark Mueller,Lourdes P. Sejismundo,Kathleen Mieras,John H. Stone +30 more
TL;DR: In patients with severe ANCA-associated vasculitis, a single course of rituximab was as effective as continuous conventional immunosuppressive therapy for the induction and maintenance of remissions over the course of 18 months.
Journal ArticleDOI
Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli.
TL;DR: The identified genetic locus, soxR (superoxide response), that positively regulates 9 of these proteins during superoxide stress may operate as an inducible defense against xenobiotics in general.
Journal ArticleDOI
CD4+ T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-γ
Dominik Mumberg,Paul A. Monach,Sherry Wanderling,Mary Philip,Alicia Y. Toledano,Robert D. Schreiber,Hans Schreiber +6 more
TL;DR: It is shown that CD4+ T cells can eliminate IFN-γ-insensitive, MHC class II-negative cancer cells by an indirect mechanism that depends on IFn-γ.
Journal ArticleDOI
A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Giant Cell Arteritis.
Carol A. Langford,David Cuthbertson,Steven R. Ytterberg,Nader Khalidi,Paul A. Monach,Simon Carette,Philip Seo,Larry W. Moreland,Michael H. Weisman,Curry L. Koening,Antoine G. Sreih,Robert Spiera,Carol A. McAlear,Kenneth J. Warrington,Christian Pagnoux,Kathleen M. McKinnon,Lindsy J. Forbess,Gary S. Hoffman,Renee Borchin,Jeffrey P. Krischer,Peter A. Merkel,Rula A. Hajj-Ali,Katherine Tuthill,Kathleen Gartner,Leah Madden,Brian Rice,Eric L. Matteson,Tanaz A. Kermani,Jane Jaquith,Naomi A. Amudala,Manuella Clark-Cotton,Sandra Messier,Julia Farquharson,Samyukta Jagadeesh,Dawn McBride,Swamy Venuturupalli,Daniel J. Wallace,Richard Phan,Nadia Verde,Denise Salinas,Jennifer Godina,Morgana L. Davids,Uzunma Udeh,Lourdes P. Sejismundo,Jennifer Harris +44 more
TL;DR: To compare the efficacy of abatacept to that of placebo for the treatment of giant cell arteritis (GCA) with a dummy pill, the objective is to establish an apples-to- apples comparison between the two treatments.