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Christopher J. Krco
Researcher at Mayo Clinic
Publications - 85
Citations - 3505
Christopher J. Krco is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Antigen & Major histocompatibility complex. The author has an hindex of 32, co-authored 85 publications receiving 3272 citations. Previous affiliations of Christopher J. Krco include University of Rochester.
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Journal ArticleDOI
PD-1 Restrains Radiotherapy-Induced Abscopal Effect
Sean S. Park,Haidong Dong,Xin Liu,Susan M. Harrington,Christopher J. Krco,Michael P. Grams,Aaron S. Mansfield,Keith M. Furutani,Kenneth R. Olivier,Eugene D. Kwon +9 more
TL;DR: SABR induces an abscopal tumor-specific immune response in both the irradiated and nonirradiated tumors, which is potentiated by PD-1 blockade, and has the potential to translate into a potent immunotherapy strategy in the management of patients with metastatic cancer.
Journal ArticleDOI
Identification of a soluble form of B7-H1 that retains immunosuppressive activity and is associated with aggressive renal cell carcinoma
Xavier Frigola,Brant A. Inman,Christine M. Lohse,Christopher J. Krco,John C. Cheville,R. Houston Thompson,Bradley C. Leibovich,Michael L. Blute,Haidong Dong,Eugene D. Kwon +9 more
TL;DR: The observations suggest that sB7-H1 may be detected in the sera of ccRCC patients and that s B7- H1 may systemically impair host immunity, thereby fostering cancer progression and subsequent poor clinical outcome.
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Tumor-Infiltrating Foxp3−CD4+CD25+ T Cells Predict Poor Survival in Renal Cell Carcinoma
Sameer Siddiqui,Xavier Frigola,Sandra Bonne-Annee,Maria Mercader,Susan M. Kuntz,Amy E. Krambeck,Shomik Sengupta,Haidong Dong,John C. Cheville,Christine M. Lohse,Christopher J. Krco,W. Scott Webster,Bradley C. Leibovich,Michael L. Blute,Keith L. Knutson,Eugene D. Kwon +15 more
TL;DR: In contrast, CD4+CD25+Foxp3− T cells, which may represent a unique set of Tregs or activated helper T cell, was significantly associated with outcome, which is in contrast to previous studies which have suggested that elimination of T Regs may augment natural and pharmacologic immunity.
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Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes.
TL;DR: Antibodies to p23 detect similar levels of p23 in all tissues tested and cross-react with a protein of the same size in mice, rabbits, guinea pigs, humans, and Saccharomyces cerevisiae, indicating that p23 is a conserved protein of broad tissue distribution.
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B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis.
Aaron S. Mansfield,Anja C. Roden,Tobias Peikert,Yuri Sheinin,Susan M. Harrington,Christopher J. Krco,Haidong Dong,Eugene D. Kwon +7 more
TL;DR: B7-H1 is expressed in a substantial proportion of malignant pleural mesotheliomas and is associated with poor survival and may have important therapeutic implications for the management of mal cancers.