H
Haidong Dong
Researcher at Mayo Clinic
Publications - 235
Citations - 25186
Haidong Dong is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Immune system & Cancer. The author has an hindex of 56, co-authored 173 publications receiving 21191 citations. Previous affiliations of Haidong Dong include Cleveland Clinic & University of Rochester.
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Journal ArticleDOI
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
Haidong Dong,Scott E. Strome,Diva R. Salomao,Hideto Tamura,Fumiya Hirano,Dallas B. Flies,Patrick C. Roche,Jun Lu,Gefeng Zhu,Koji Tamada,Vanda A. Lennon,Esteban Celis,Lieping Chen +12 more
TL;DR: It is reported here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1 and the findings have implications for the design of T cell–based cancer immunotherapy.
Journal ArticleDOI
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
TL;DR: A previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses is defined.
Journal ArticleDOI
Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response
Chen Gang,Alexander C. Huang,Wei Zhang,Wei Zhang,Gao Zhang,Wu Min,Wei Xu,Zi-Li Yu,Jiegang Yang,Jiegang Yang,Beike Wang,Beike Wang,Honghong Sun,Hou-Fu Xia,Qiwen Man,Wenqun Zhong,Wenqun Zhong,Leonardo F. Antelo,Bin Wu,Xuepeng Xiong,Xiaoming Liu,Lei Guan,Lei Guan,Ting Li,Ting Li,Shujing Liu,Ruifeng Yang,Youtao Lu,Liyun Dong,Suzanne McGettigan,Rajasekharan Somasundaram,Ravi Radhakrishnan,Gordon B. Mills,Yiling Lu,Junhyong Kim,Youhai H. Chen,Haidong Dong,Yi-Fang Zhao,Giorgos C. Karakousis,Tara C. Mitchell,Lynn M. Schuchter,Meenhard Herlyn,E. John Wherry,Xiaowei Xu,Wei Guo +44 more
TL;DR: It is reported that metastatic melanomas release extracellular vesicles, mostly in the form of exosomes, that carry PD-L1 on their surface, suggesting a mechanism by which tumours could evade the immunesystem, and the potential application ofExosomal PD- L1 to monitor patient responses to checkpoint therapies.
Journal ArticleDOI
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.
Tyler J. Curiel,Shuang Wei,Haidong Dong,Xavier Alvarez,Pui Cheng,Peter Mottram,Roman Krzysiek,Keith L. Knutson,Ben Daniel,Maria Carla Zimmermann,Odile David,Matthew E. Burow,Alan N. Gordon,Nina Dhurandhar,Leann Myers,Ruth E. Berggren,Akseli Hemminki,Ronald D. Alvarez,Dominique Emilie,David T. Curiel,Lieping Chen,Weiping Zou +21 more
TL;DR: It is shown that a fraction of blood monocyte-derived myeloid dendritic cells (MDCs) express B7-H1, a member of the B7 family, on the cell surface, which could be further upregulated by tumor environmental factors.
Journal Article
Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity
Fumiya Hirano,Katsumi Kaneko,Hideto Tamura,Haidong Dong,Shengdian Wang,Shengdian Wang,Masao Ichikawa,Masao Ichikawa,Cecilia Rietz,Cecilia Rietz,Dallas B. Flies,Dallas B. Flies,Julie S. Lau,Gefeng Zhu,Gefeng Zhu,Koji Tamada,Koji Tamada,Lieping Chen,Lieping Chen +18 more
TL;DR: It is reported here that constitutive or inducible expression of B7-H1, a B7 family molecule widely expressed by cancers, confers resistance to therapeutic anti-CD137 antibody in mice with established tumors and implicate new approaches for immunotherapy of human cancers.