E
Eugene D. Kwon
Researcher at Mayo Clinic
Publications - 188
Citations - 16800
Eugene D. Kwon is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 60, co-authored 164 publications receiving 15203 citations. Previous affiliations of Eugene D. Kwon include University of Rochester & National Institutes of Health.
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Journal ArticleDOI
Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial
Eugene D. Kwon,Charles G. Drake,Howard I. Scher,Karim Fizazi,Alberto Bossi,Alfons J.M. van den Eertwegh,Michael Krainer,Nadine Houede,Ricardo Santos,Hakim Mahammedi,Siobhan Ng,Michele Maio,Fabio Franke,Santhanam Sundar,Neeraj Agarwal,Andries M. Bergman,Tudor Ciuleanu,Ernesto Korbenfeld,Lisa Sengeløv,Steinbjørn Hansen,Christopher J. Logothetis,Tomasz M. Beer,M. Brent McHenry,Paul Gagnier,David R. Liu,Winald R. Gerritsen +25 more
TL;DR: There was no significant difference between the ipilimumab group and the placebo group in terms of overall survival in the primary analysis, but there were signs of activity with the drug that warrant further investigation.
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Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up.
R. Houston Thompson,Susan M. Kuntz,Bradley C. Leibovich,Haidong Dong,Christine M. Lohse,W. Scott Webster,Shomik Sengupta,Igor Frank,Alexander S. Parker,Horst Zincke,Michael L. Blute,Thomas J. Sebo,John C. Cheville,Eugene D. Kwon +13 more
TL;DR: RCC patients with tumor B7-H1 may function as a key determinant in RCC, abrogating immune responses directed against this immunogenic tumor, causing rapid cancer progression and accelerated rates of mortality.
Journal Article
Clinical Significance of Defective Dendritic Cell Differentiation in Cancer
Bond Almand,John R. Resser,Brian R. Lindman,Sorena Nadaf,Joseph I. Clark,Eugene D. Kwon,David P. Carbone,Dmitry I. Gabrilovich +7 more
TL;DR: Data indicate that defective DC function in cancer patients is the result of decreased numbers of competent DCs and the accumulation of immature cells, which may have significant clinical implications.
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Radical Nephrectomy for pT1a Renal Masses May be Associated With Decreased Overall Survival Compared With Partial Nephrectomy
R. Houston Thompson,Stephen A. Boorjian,Christine M. Lohse,Bradley C. Leibovich,Eugene D. Kwon,John C. Cheville,Michael L. Blute +6 more
TL;DR: The results suggest that, compared with partial nephrectomy, radical neph rectomy is associated with decreased overall survival in younger patients with small renal masses.
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PD-1 Is Expressed by Tumor-Infiltrating Immune Cells and Is Associated with Poor Outcome for Patients with Renal Cell Carcinoma
R. Houston Thompson,Haidong Dong,Christine M. Lohse,Bradley C. Leibovich,Michael L. Blute,John C. Cheville,Eugene D. Kwon +6 more
TL;DR: Interactions between immune cell PD-1 and B7-H1 may promote cancer progression by contributing to immune dysfunction in patients with RCC, and levels of immune cells expressingPD-1 were increased in Patients with high-risk RCC tumors.