C
Christopher K. Mathews
Researcher at Oregon State University
Publications - 144
Citations - 5646
Christopher K. Mathews is an academic researcher from Oregon State University. The author has contributed to research in topics: Ribonucleotide reductase & DNA replication. The author has an hindex of 41, co-authored 144 publications receiving 5387 citations. Previous affiliations of Christopher K. Mathews include University of Arizona & University of Washington.
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Journal ArticleDOI
Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools.
TL;DR: The persistence of basal dNTP levels in HU-arrested cells and partial bypass of the arrest in cells that had preaccumulated dN TPs suggest that cells have a mechanism for arresting DNA chain elongation when d NTP levels are not maintained above a critical threshold.
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DNA precursor metabolism and genomic stability
TL;DR: This review focuses on developments since 1994, when the field was last reviewed comprehensively, and focuses on novel aspects of dNTP pool regulation, metabolism and hypermutagenesis in the mitochondrial genome.
Journal ArticleDOI
Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability
Bernard A. Kunz,Susanne E. Kohalmi,Thomas A. Kunkel,Christopher K. Mathews,Evan M. McIntosh,John A. Reidy +5 more
TL;DR: In this article, the biochemical and genetic mechanisms responsible for regulating the production and relative amounts of intracellular DNA precursors, describe the many outcomes of perturbations in DNA precursor levels, and discuss implications of such imbalances for sensitivity to DNA-damaging agents, population monitoring, and human diseases.
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Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.
Sudha Mannava,Vladimir Grachtchouk,Vladimir Grachtchouk,Linda J. Wheeler,Linda J. Wheeler,Michael Im,Michael Im,Dazhong Zhuang,Dazhong Zhuang,Elena G. Slavina,Elena G. Slavina,Christopher K. Mathews,Christopher K. Mathews,Donna S. Shewach,Mikhail A. Nikiforov,Mikhail A. Nikiforov +15 more
TL;DR: A novel functional link between C-MYC and dNTP metabolism is established and its role in proliferation of tumor cells is identified.
Journal ArticleDOI
Deoxyribonucleotide metabolism, mutagenesis and cancer.
TL;DR: The extent to which aspects of deoxyribonucleotide metabolism contribute to the understanding of both carcinogenesis and to the effective use of anticancer agents is considered.