Christopher Lau

TL;DR: Based on current understanding of the developmental effects of PFOS and PFOA in rodents, several avenues of research are suggested that would further support the risk assessment of these perfluorinated organic chemicals.

TL;DR: Both maternal and developmental toxicity of PFOS are demonstrated in the rat and mouse, with a host of birth defects, including cleft palate, anasarca, ventricular septal defect, and enlargement of the right atrium seen.

TL;DR: Data indicate that while some effects of Aroclor 1254 exposure are dissimilar to drug-induced hypothyroidism, effects on hormone levels and body weight are comparable and may reflect the effects of thyroid hormone disruption on the development of the cochlea.

TL;DR: The toxicokinetic profiles of various PFAAs among animal models and humans, and the biological processes that are responsible for these observations are addressed, to examine the possible modes of action that determine the PFAA toxicities observed in animal models, and their relevance to human health risks.

TL;DR: The results of the studies of the 2 cell lines and the in vivo exposure were comparable, suggesting that the inhibitory effects of the selected perfluorinated compounds on GJIC were neither species- nor tissue-specific and can occur both in vitro and in vivo.