C
Christopher-Michael Gale
Researcher at Harvard University
Publications - 2
Citations - 4219
Christopher-Michael Gale is an academic researcher from Harvard University. The author has contributed to research in topics: Receptor tyrosine kinase & ERBB3. The author has an hindex of 1, co-authored 2 publications receiving 3968 citations.
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Journal ArticleDOI
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Jeffrey A. Engelman,Kreshnik Zejnullahu,Tetsuya Mitsudomi,Youngchul Song,Courtney Hyland,Joon Oh Park,Neal I. Lindeman,Christopher-Michael Gale,Xiaojun Zhao,James J. Christensen,Takayuki Kosaka,Alison J. Holmes,Andrew M. Rogers,Federico Cappuzzo,Tony Mok,Charles Lee,Bruce E. Johnson,Lewis C. Cantley,Pasi A. Jänne +18 more
TL;DR: It is proposed that MET amplification may promote drug resistance in other ERBB-driven cancers as well after it was found that amplification of MET causes gefitinib resistance by driving ERBB3 (HER3)–dependent activation of PI3K, a pathway thought to be specific to EGFR/ERBB family receptors.
Journal ArticleDOI
D2-07: Mechanisms of activating PI3K signaling in lung cancers that become resistant EGFR tyrosine kinase inhibitors
Jeffrey A. Engelman,Kreshnik Zejnullahu,Tetsuya Mitsudomi,Courtney Hyland,Joon Oh Park,Neal I. Lindeman,Christopher-Michael Gale,Xiaojun Zhao,James D. Christensen,Rogers M. Rogers,Federico Cappuzzo,Tony Mok,Charles Lee,Johnson E. Bruce,Lewis C. Cantley,Pasi A. Jänne +15 more