C
Christopher Poon
Researcher at University of Southern California
Publications - 25
Citations - 1931
Christopher Poon is an academic researcher from University of Southern California. The author has contributed to research in topics: Peptide amphiphile & Drug delivery. The author has an hindex of 16, co-authored 24 publications receiving 1487 citations. Previous affiliations of Christopher Poon include University of Chicago & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy
Chunbai He,Xiaopin Duan,Nining Guo,Christina Chan,Christopher Poon,Ralph R. Weichselbaum,Wenbin Lin +6 more
TL;DR: The use of immunogenic nanoparticles to augment the antitumour efficacy of PD-L1 antibody-mediated cancer immunotherapy mediates regression of both light-irradiated primary tumours and non-IRradiated distant tumours by inducing a strong tumour-specific immune response.
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Metal-organic frameworks as sensory materials and imaging agents.
TL;DR: Although still in their infancy, it is believed that the compositional tunability and mild synthetic conditions of NMOF imaging agents should greatly facilitate their further development for clinical translation.
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Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy
TL;DR: This study establishes NCPs as a promising drug delivery platform for cancer therapy by using them as nanotherapeutics with enhanced antitumor activities and reports the self-assembly of zinc bisphosphonate N CPs that carry 48±3 wt% cisplatin prodrug and 45±5 wt%.
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Self-assembled nanoscale coordination polymers carrying oxaliplatin and gemcitabine for synergistic combination therapy of pancreatic cancer
TL;DR: A novel nanoparticle platform based on nanoscale coordination polymer-1 (NCP-1) for simultaneous delivery of two chemotherapeutics, oxaliplatin and gemcitabine monophosphate (GMP), at 30 wt.% and 12.% drug loadings is developed.
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Nanoscale Coordination Polymers Codeliver Chemotherapeutics and siRNAs to Eradicate Tumors of Cisplatin-Resistant Ovarian Cancer.
TL;DR: Novel long-circulating, self-assembled core-shell nanoscale coordination polymer nanoparticles that efficiently deliver multiple therapeutics with different mechanisms of action to enhance synergistic therapeutic effects promise a more effective chemotherapeutic treatment for many challenging cancers.