Christopher S. McKee

TL;DR: It is suggested that THC activates noncanonical autophagy-mediated apoptosis of melanoma cells, suggesting that cytotoxic autophile induction with Sativex warrants clinical evaluation for metastatic disease.

TL;DR: It is shown that THC (but not nutrient deprivation) increases the dihydroceramide:ceramide ratio in the endoplasmic reticulum of glioma cells, and this alteration is directed to autophagosomes and autolysosomes to promote lysosomal membrane permeabilization, cathepsin release and the subsequent activation of apoptotic cell death.

TL;DR: It is suggested that the regulation of Mcl‐1 expression by BRAF signalling is increased by oncogenic activation of BRAF, revealing a mechanism of apoptotic resistance which may be overcome by the use of more specifically targeted M cl‐1 inhibitors.

TL;DR: Combined AKT inhibition and chloroquine treatment of MET 4 cSCC cells resulted in significantly enhanced inhibition of cell viability and apoptosis induced by clinically achievable concentrations of docetaxel (P < 0.001), indicating that inhibition of both autophagy and AKT represents an effective and viable therapeutic strategy to increase the cytotoxicity ofDocetaxe for the treatment of advanced cS CC.