José González-Martínez

TL;DR: It is shown that THC (but not nutrient deprivation) increases the dihydroceramide:ceramide ratio in the endoplasmic reticulum of glioma cells, and this alteration is directed to autophagosomes and autolysosomes to promote lysosomal membrane permeabilization, cathepsin release and the subsequent activation of apoptotic cell death.

TL;DR: Inhibition of the MDK/ALK axis may be a therapeutic strategy to target GICs in GBM patients by controlling the autophagic degradation of the transcription factor SOX9.

TL;DR: In this article, the authors studied the dynamics of the meiotic centrosomes in male mouse during both meiotic divisions and found that duplicated centrosome duplicates occur in leptotene/zygotene transition and interkinesis.

TL;DR: In this article, a series of CRISPR/Cas9-mediated genetic knockouts were used to generate a mouse model of microcephaly and showed that Cep135 deficiency results in centriole duplication, TP53 activation and cell death of neural progenitors.

TL;DR: It is found that Aurora A is necessary for CD8+ T cell-mediated antiviral response, in an in vivo model of vaccinia virus infection and Aurora A activity is, indeed, needed for the proper effector function of cytotoxic T lymphocytes and for their activity against viral threats.