C
Christopher T. Lee
Researcher at University of Alberta
Publications - 2
Citations - 1470
Christopher T. Lee is an academic researcher from University of Alberta. The author has contributed to research in topics: Glycolysis & Cancer. The author has an hindex of 2, co-authored 2 publications receiving 1383 citations.
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Journal ArticleDOI
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
Sébastien Bonnet,Stephen L. Archer,Joan Allalunis-Turner,Alois Haromy,Christian Beaulieu,Richard B. Thompson,Christopher T. Lee,Gary D. Lopaschuk,Lakshmi Puttagunta,Sandra Bonnet,Gwyneth Harry,Kyoko Hashimoto,Christopher J. Porter,Miguel A. Andrade,Bernard Thébaud,Evangelos D. Michelakis +15 more
TL;DR: The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted and the orally available DCA is a promising selective anticancer agent.
Journal ArticleDOI
5'-AMP-activated protein kinase increases glucose uptake independent of GLUT4 translocation in cardiac myocytes.
TL;DR: It is demonstrated that while insulin has no detectable effect on glucose uptake, phenformin-induced AMPK activation increases glucose uptake 2.5-fold, and suggest that AMPK is a major regulator of glucose uptake in cardiac myocytes.