C
Christos Constantinidis
Researcher at Wake Forest University
Publications - 113
Citations - 7293
Christos Constantinidis is an academic researcher from Wake Forest University. The author has contributed to research in topics: Working memory & Prefrontal cortex. The author has an hindex of 37, co-authored 96 publications receiving 6003 citations. Previous affiliations of Christos Constantinidis include Wake Forest Baptist Medical Center & Vanderbilt University.
Papers
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Journal ArticleDOI
Demixed principal component analysis of neural population data
Dmitry Kobak,Wieland Brendel,Wieland Brendel,Christos Constantinidis,Claudia E. Feierstein,Adam Kepecs,Zachary F. Mainen,Xue-Lian Qi,Ranulfo Romo,Naoshige Uchida,Christian K. Machens +10 more
TL;DR: A new dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components and exposes the dependence of the neural representation on task parameters such as stimuli, decisions, or rewards is demonstrated.
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Bump attractor dynamics in prefrontal cortex explains behavioral precision in spatial working memory
TL;DR: In this article, the authors analyzed monkey data and found model-derived predictive relationships between the variability of prefrontal activity in the delay and the fine details of recalled spatial location, as evident in trial-to-trial imprecise oculomotor responses.
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The neuroscience of working memory capacity and training
TL;DR: Human imaging studies and neurophysiological recordings in non-human primates, together with computational modelling studies, reveal that training increases the activity of prefrontal neurons and the strength of connectivity in the prefrontal cortex and between the prefrontal and parietal cortex.
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Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory
Xiao Jing Wang,Jesper Tegnér,Jesper Tegnér,Christos Constantinidis,Christos Constantinidis,Patricia S. Goldman-Rakic +5 more
TL;DR: This work suggests a framework for understanding the division of labor and cooperation among different inhibitory cell types in a recurrent cortical circuit in which three major subtypes of interneurons play distinct roles.
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A role for inhibition in shaping the temporal flow of information in prefrontal cortex
TL;DR: Using simultaneous recordings in monkeys, inhibitory interactions between neurons active at different time points relative to the cue presentation, delay interval and response period of a working memory task suggest an important role of inhibition in the cerebral cortex.