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Chu-Jun Liu
Researcher at Peking University
Publications - 15
Citations - 598
Chu-Jun Liu is an academic researcher from Peking University. The author has contributed to research in topics: Macaque & RNA. The author has an hindex of 8, co-authored 13 publications receiving 492 citations.
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Journal ArticleDOI
Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway.
Xiao Zhou,Xiaorui Han,Ann Wittfeldt,Jingzhi Sun,Chu-Jun Liu,Xiaoxia Wang,Li-Ming Gan,Huiqing Cao,Zicai Liang +8 more
TL;DR: The newly identified TNF-α-NF-κB-ANRIL/YY1-IL6/8 pathway enhances understanding of the etiology of CAD and provides potential therapeutic target for treatment of CAD.
Journal ArticleDOI
Hominoid-Specific De Novo Protein-Coding Genes Originating from Long Non-Coding RNAs
Chen Xie,Yong Zhang,Jia-Yu Chen,Chu-Jun Liu,Wei-Zhen Zhou,Ying Li,Mao Zhang,Rongli Zhang,Liping Wei,Chuan-Yun Li +9 more
TL;DR: It is suggested that at least a portion of long non-coding RNAs, especially those with active and regulated transcription, may serve as a birth pool for protein-c coding genes, which are then further optimized at the transcriptional level.
Journal ArticleDOI
RNA editome in rhesus macaque shaped by purifying selection.
Jia-Yu Chen,Zhiyu Peng,Rongli Zhang,Xin-Zhuang Yang,Bertrand Chin-Ming Tan,Huaying Fang,Chu-Jun Liu,Mingming Shi,Zhi-Qiang Ye,Yong Zhang,Minghua Deng,Xiuqin Zhang,Chuan-Yun Li +12 more
TL;DR: An accurate and quantitative profile of the RNA editome for rhesus macaque is reported, highlighting RNA editing as a widespread functional regulation in primate evolution, and provides an informative framework for further understanding RNA editing in human.
Journal ArticleDOI
Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates.
Jia-Yu Chen,Qing Sunny Shen,Wei-Zhen Zhou,Jiguang Peng,Bin Z. He,Yumei Li,Chu-Jun Liu,Xuke Luan,Wanqiu Ding,Shuxian Li,C. T. Chen,Bertrand Chin-Ming Tan,Yong Zhang,Aibin He,Chuan-Yun Li +14 more
TL;DR: A mechanism for creation of functional de novo proteins from ancestral lncRNAs during the primate evolution is proposed, which may contribute to human-specific genetic novelties by taking advantage of existed genomic contexts.
Journal ArticleDOI
Small activating RNA binds to the genomic target site in a seed-region-dependent manner
Xing Meng,Qian Jiang,Nannan Chang,Xiaoxia Wang,Chu-Jun Liu,Jing-Wei Xiong,Huiqing Cao,Zicai Liang +7 more
TL;DR: It is demonstrated that saRNAs work via an on-site mechanism by binding to target genomic DNA in a seed-region-dependent manner, reminiscent of miRNA-like target recognition.