Z
Zicai Liang
Researcher at Peking University
Publications - 154
Citations - 10001
Zicai Liang is an academic researcher from Peking University. The author has contributed to research in topics: Small interfering RNA & Electroporation. The author has an hindex of 48, co-authored 151 publications receiving 8891 citations. Previous affiliations of Zicai Liang include Santaris Pharma a/s & Karolinska Institutet.
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Journal ArticleDOI
Antisense Transcription in the Mammalian Transcriptome
Shintaro Katayama,Yasuhiro Tomaru,Takeya Kasukawa,Kazunori Waki,Misato Nakanishi,Mari M. Nakamura,Hiromi Nishida,C. C. Yap,M. Suzuki,Jun Kawai,Harukazu Suzuki,Piero Carninci,Yoshihide Hayashizaki,Christine A. Wells,Martin C. Frith,Timothy Ravasi,Ken C Pang,Ken C Pang,Ken C Pang,Jennifer Hallinan,John S. Mattick,David A. Hume,Leonard Lipovich,Serge Batalov,Pär G. Engström,Yumi Mizuno,Mohammad Ali Faghihi,Mohammad Ali Faghihi,Albin Sandelin,Alistair M. Chalk,Salim Mottagui-Tabar,Salim Mottagui-Tabar,Zicai Liang,Boris Lenhard,Claes Wahlestedt,Claes Wahlestedt +35 more
TL;DR: Experimental evidence that perturbation of an antisense RNA can alter the expression of sense messenger RNAs is presented, suggesting that antisense transcription contributes to control of transcriptional outputs in mammals.
Journal ArticleDOI
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
Joacim Elmén,Håkan Thonberg,Karl Ljungberg,Miriam Frieden,Majken Westergaard,Yunhe Xu,Britta Wahren,Zicai Liang,Henrik Ørum,Troels Koch,Claes Wahlestedt +10 more
TL;DR: It is shown that incorporation of LNA substantially enhances serum half-life of siRNA's, which is a key requirement for therapeutic use and evidence that LNA is compatible with the intracellular siRNA machinery and can be used to reduce undesired, sequence-related off-target effects.
Journal ArticleDOI
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Defang Li,Jin Liu,Baosheng Guo,Chao Liang,Lei Dang,Cheng Lu,Cheng Lu,Xiaojuan He,Xiaojuan He,Hilda Y. S. Cheung,Liang Xu,Changwei Lu,Bing He,Biao Liu,Atik Badshah Shaikh,Fangfei Li,Luyao Wang,Zhijun Yang,Doris W.T. Au,Songlin Peng,Zong-Kang Zhang,Bao-Ting Zhang,Xiaohua Pan,Xiaohua Pan,Airong Qian,Airong Qian,Peng Shang,Peng Shang,Lianbo Xiao,Lianbo Xiao,Baohong Jiang,Chris K C Wong,Jiake Xu,Zhaoxiang Bian,Zicai Liang,De-An Guo,Hailong Zhu,Weihong Tan,Aiping Lu,Ge Zhang +39 more
TL;DR: The results suggest that osteoclast-derived exosomal miR-214-3p transfers to osteoblasts to inhibit bone formation, which may be a strategy for treating skeletal disorders involving a reduction in bone formation.
Journal ArticleDOI
Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte
Shutao Guo,Yuanyu Huang,Qiao Jiang,Yun Sun,Liandong Deng,Zicai Liang,Quan Du,Jinfeng Xing,Yuliang Zhao,Paul C. Wang,Anjie Dong,Xing-Jie Liang +11 more
TL;DR: The results demonstrate the feasibility of using charge-reversal functional gold nanoparticles as a means of improving the nucleic acid delivery efficiency.
Journal ArticleDOI
Hypoxia-independent angiogenesis in adipose tissues during cold acclimation.
Yuan Xue,Natasa Petrovic,Renhai Cao,Ola Larsson,Sharon Lim,Shaohua Chen,Helena M. Feldmann,Zicai Liang,Zhenping Zhu,Jan Nedergaard,Barbara Cannon,Yihai Cao +11 more
TL;DR: It is shown that exposure of mice to cold led to activation of angiogenesis in both white and brown adipose tissues, and VEGFR1 blockage resulted in the opposite effects: increased adipose vascularity and nonshivering thermogenesis capacity.