C
Chun Chen Ho
Researcher at Academia Sinica
Publications - 8
Citations - 662
Chun Chen Ho is an academic researcher from Academia Sinica. The author has contributed to research in topics: SUMO protein & Transforming growth factor. The author has an hindex of 5, co-authored 8 publications receiving 603 citations.
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Journal ArticleDOI
Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors.
Ding Yen Lin,Yen Sung Huang,Jen Chong Jeng,Hong Yi Kuo,Che Chang Chang,Ting Ting Chao,Chun Chen Ho,Yunching Chen,Tong Ping Lin,Hsin I. Fang,Chih Chang Hung,Ching Shu Suen,Ming-Jing Hwang,Kun Sang Chang,Gerd G. Maul,Hsiu Ming Shih +15 more
TL;DR: It is demonstrated that arsenic trioxide-induced sumoylation of PML correlates with a change of endogenous Daxx partitioning from GR-regulated gene promoter to PODs and a relief of DAXx repression on GR target gene expression, which provides mechanistic insights into DaxX in SUMO-dependent transcriptional control and subnuclear compartmentalization.
Journal ArticleDOI
Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation
Che Chang Chang,Mandar T. Naik,Yen Sung Huang,Jen Chong Jeng,Pei Hsin Liao,Hong Yi Kuo,Chun Chen Ho,Yung Lin Hsieh,Yung Lin Hsieh,Chiou-Hong Lin,Nai-Jia Huang,Nandita M. Naik,Camy C.H. Kung,Camy C.H. Kung,Shu-Yu Lin,Ruey-Hwa Chen,Kun Sang Chang,Tai Huang Huang,Tai Huang Huang,Hsiu Ming Shih,Hsiu Ming Shih +20 more
TL;DR: Structural insights are provided into the Daxx-SIM:SUMO-1 complex, a model of SIM phosphorylation-enhanced SUMO paralog-selective modification and interaction, and phosphorylated-regulated DAXx function in apoptosis.
Journal ArticleDOI
Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.
Yung Lin Hsieh,Yung Lin Hsieh,Hong Yi Kuo,Che Chang Chang,Che Chang Chang,Mandar T. Naik,Pei Hsin Liao,Chun Chen Ho,Tien Chi Huang,Tien Chi Huang,Jen Chong Jeng,Pang-Hung Hsu,Ming-Daw Tsai,Tai Huang Huang,Tai Huang Huang,Hsiu Ming Shih +15 more
TL;DR: It is suggested that Ubc9 acetylation/deacetylation serves as a dynamic switch for NDSM substrate sumoylation and a previously undescribed SIRT1/Ubc9 regulatory axis in the modulation of protein sumoylated and the hypoxia response is reported.
Journal ArticleDOI
Author Correction: The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis
Che Chang Chang,Yen Sung Huang,Ying Mei Lin,Chia Ju Lin,Jen Chong Jeng,Shin Mei Liu,Tsai Ling Ho,Ruei Ting Chang,Chun A. Changou,Chun Chen Ho,Hsiu-Ming Shih +10 more
TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Journal ArticleDOI
The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis.
Che Chang Chang,Yen Sung Huang,Ying Mei Lin,Chia Ju Lin,Jen Chong Jeng,Shin Mei Liu,Tsai Ling Ho,Ruei Ting Chang,Chun A. Changou,Chun Chen Ho,Hsiu-Ming Shih +10 more
TL;DR: SENP2 regulates its substrate for desumoylation, and also the role of SENP2 in TGF-β induced cancer cell migration is shown, suggesting that the interaction and desumoyslation between SENP 2 and Smad4 promote cell migration in triple-negative breast cancer cells.