C
Che Chang Chang
Researcher at Academia Sinica
Publications - 12
Citations - 1097
Che Chang Chang is an academic researcher from Academia Sinica. The author has contributed to research in topics: SUMO protein & Death-associated protein 6. The author has an hindex of 11, co-authored 12 publications receiving 1008 citations. Previous affiliations of Che Chang Chang include National Defense Medical Center & National Taiwan University.
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Journal ArticleDOI
Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors.
Ding Yen Lin,Yen Sung Huang,Jen Chong Jeng,Hong Yi Kuo,Che Chang Chang,Ting Ting Chao,Chun Chen Ho,Yunching Chen,Tong Ping Lin,Hsin I. Fang,Chih Chang Hung,Ching Shu Suen,Ming-Jing Hwang,Kun Sang Chang,Gerd G. Maul,Hsiu Ming Shih +15 more
TL;DR: It is demonstrated that arsenic trioxide-induced sumoylation of PML correlates with a change of endogenous Daxx partitioning from GR-regulated gene promoter to PODs and a relief of DAXx repression on GR target gene expression, which provides mechanistic insights into DaxX in SUMO-dependent transcriptional control and subnuclear compartmentalization.
Journal ArticleDOI
Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation
Che Chang Chang,Mandar T. Naik,Yen Sung Huang,Jen Chong Jeng,Pei Hsin Liao,Hong Yi Kuo,Chun Chen Ho,Yung Lin Hsieh,Yung Lin Hsieh,Chiou-Hong Lin,Nai-Jia Huang,Nandita M. Naik,Camy C.H. Kung,Camy C.H. Kung,Shu-Yu Lin,Ruey-Hwa Chen,Kun Sang Chang,Tai Huang Huang,Tai Huang Huang,Hsiu Ming Shih,Hsiu Ming Shih +20 more
TL;DR: Structural insights are provided into the Daxx-SIM:SUMO-1 complex, a model of SIM phosphorylation-enhanced SUMO paralog-selective modification and interaction, and phosphorylated-regulated DAXx function in apoptosis.
Journal ArticleDOI
SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx
Hong Yi Kuo,Che Chang Chang,Che Chang Chang,Jen Chong Jeng,Jen Chong Jeng,Hui Mei Hu,Ding Yen Lin,Gerd G. Maul,Roland P.S. Kwok,Hsiu Ming Shih,Hsiu Ming Shih +10 more
TL;DR: It is shown that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling events, can be modified by SUMO-1 at lysine residues 999, 1034, and 1057 both in vitro and in vivo.
Journal ArticleDOI
Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.
TL;DR: Daxx suppresses Smad 4-mediated transcriptional activity by direct interaction with the sumoylated Smad4 and identifies a novel role of Daxx in regulating transforming growth factor β signaling.
Journal ArticleDOI
SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function
Chun Hau Chen,Che Chang Chang,Tae Ho Lee,Man-Li Luo,Pengyu Huang,Pei Hsin Liao,Shuo Wei,Fu An Li,Ruey-Hwa Chen,Xiao Zhen Zhou,Hsiu Ming Shih,Kun Ping Lu +11 more
TL;DR: This work shows that Pin1 is SUMOylated on Lys6 in the WW domain and on Lys63 in the PPIase domain and identifies a critical role for SENP1-mediated deSUMOylation in promoting Pin1 function during tumorigenesis.