C
Chun-Kwok Wong
Researcher at The Chinese University of Hong Kong
Publications - 185
Citations - 5627
Chun-Kwok Wong is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Chemokine & Cytokine. The author has an hindex of 39, co-authored 182 publications receiving 4705 citations.
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Journal ArticleDOI
TLR-4 may mediate signaling pathways of Astragalus polysaccharide RAP induced cytokine expression of RAW264.7 cells.
Wei Wei,Haitao Xiao,Wan-Rong Bao,Dik-Lung Ma,Chung-Hang Leung,Xiao-Qiang Han,Chun-Hay Ko,Clara Bik-San Lau,Chun-Kwok Wong,Kwok-Pui Fung,Ping-Chung Leung,Zhaoxiang Bian,Quan-Bin Han +12 more
TL;DR: It has been found that RAP itself did not have any cytotoxic effect on mouse mammary carcinoma 4T1 cells, but it significantly enhanced cytotoxicity of the supernatant of RAW264.7 cells, suggesting that TLR4 is a receptor of RAP and mediates its immunomodulating activity.
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Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis
Phyllis F. Y. Cheung,Chun-Kwok Wong,Amy Wing Yin Ho,Shuiqing Hu,Da-Peng Chen,Christopher W.K. Lam,Christopher W.K. Lam +6 more
TL;DR: A crucial immunopathological role is suggested in AD through activation of eosinophils-keratinocytes system through functional cell surface IL-31 receptor.
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Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A(H1N1) virus pneumonia.
Nelson Lee,Paul K.S. Chan,Chun-Kwok Wong,Ka-Tak Wong,Kin-Wing Choi,Gavin M. Joynt,Philip T H Lam,Martin C.W. Chan,Bonnie C. K. Wong,Grace Lui,Winnie W. Y. Sin,Rity Y. K. Wong,Wai-Yip Lam,Apple C.M. Yeung,Ting Fan Leung,Hing-Yu So,Alex W.Y. Yu,Joseph J.Y. Sung,David S.C. Hui +18 more
TL;DR: In severe 2009 H1N1 pneumonia, viral clearance is slow with treatment, particularly in the lower respiratory tract, and a more sustained antiviral regime appears warranted.
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Tumor necrosis factor-α up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways
TL;DR: TNF-alpha can play a crucial role in the immunopathogenesis of nephritis by the induction of CCL2, ICAM-1 and VCam-1 expression via the activation of the intracellular MAPK signaling pathway, which may contribute to macrophage and lymphocyte infiltration.
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Plasma concentration of thymus and activation-regulated chemokine is elevated in childhood asthma
TL;DR: The results suggest that plasma TARC concentrations are elevated in childhood asthma, and this marker is also linked to plasma total IgE levels and cat allergen sensitization.