Chun-Ming Huang

TL;DR: Mutational analysis showed that the enhanced tumorigenicity was dependent on intrinsic tyrosine kinase activity and was mediated through the carboxyl terminus, suggesting that the biological functions of ΔEGFR are due to low constitutive activation with mitogenic effects amplified by failure to attenuate signaling by receptor down-regulation.

TL;DR: It is suggested that VEGF plays a major angiogenic role in glioblastoma, one of the most highly vascularized human cancers, through its role in the development of new capillary networks from the normal microvasculature of the host.

TL;DR: RAG1 appears to have a binary structure, each half containing multiple regions that can act as NLSs, binding sites for the SRP1/Rch1 family, and RNA binding domains, indicating that RAG1 has affinity for RNA or ssDNA.

TL;DR: The findings here show that hyperglycemia induces the expression of GLUT1, OGT, and HIF-1α to cause CCRT tolerance in rectal cancer and suggest that combining Hif-1 α inhibitors could reverse radioresistance in a high glucose environment.