Chunhua Yin

TL;DR: In vivo biodistribution suggested that NPs with slight negative charges and particle size of 150 nm were tended to accumulate in tumor more efficiently, and could serve as a guideline in the rational design of drug nanocarriers with maximized therapeutic efficacy and predictable in vivo properties.

TL;DR: Self-assembled nanoparticles between TMC-Cys and protein drugs could be an effective and safe oral delivery system and biocompatibility assessment revealed lack of toxicity of TMC -Cys NP.

TL;DR: Due to the cross-linked O-CMC network, in vitro muco-adhesive force and mechanical properties, including compression and tensile modulus, of the SPH-IPN were greatly improved when compared with the CSPH.

TL;DR: Rhodamine B labeled carboxylated chitosan grafted nanoparticles with different particle sizes and similar Zeta potentials provided guidelines for the rational design of oral nanocarriers for protein drugs in terms of particle size.

TL;DR: Multi-layered nanocomplexes were designed here to provide smart co-delivery of doxorubicin (DOX) and vascular endothelial growth factor (VEGF) siRNA and served as an effective and safe vector to maximize synergistic effect of chemodrugs and therapeutic genes.