C
Ciaran O’Reilly
Researcher at Trinity College, Dublin
Publications - 18
Citations - 288
Ciaran O’Reilly is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Macrophage migration inhibitory factor & Pseudomonas aeruginosa. The author has an hindex of 8, co-authored 17 publications receiving 218 citations. Previous affiliations of Ciaran O’Reilly include University College Dublin & National University of Ireland, Galway.
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Journal ArticleDOI
Targeting MIF in Cancer: Therapeutic Strategies, Current Developments, and Future Opportunities
TL;DR: This review highlights the current state of the art, which presents MIF, and the second member of the MIF structural superfamily, d‐DT (MIF2), as significant mediators in the inflammatory–cancer axis.
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Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer.
Leona Mawhinney,Leona Mawhinney,Michelle E. Armstrong,Ciaran O’Reilly,Richard Bucala,Lin Leng,Gunter Fingerle-Rowson,Darren Fayne,Michael P. Keane,Aisling Tynan,Lewena Maher,Gordon Cooke,David Lloyd,Helen Conroy,Seamas C. Donnelly +14 more
TL;DR: A novel inhibitor is identified that blocks the hydrophobic pocket of MIF, which houses its specific tautomerase enzymatic activity, and it is demonstrated that targeting this unique active site significantly attenuates lung cancer growth in in vitro and in vivo systems.
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Synthesis of α-S-Glycosphingolipids Based on Uronic Acids
Ciaran O’Reilly,Paul V. Murphy +1 more
TL;DR: The synthesis of S-glycosphingolipids based on uronic acids is described, analogous to the highly immunostimulatory antigens isolated from the cell walls of bacteria of the Sphingomonas family.
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Decorated macrocycles via ring-closing double-reductive amination. identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor.
Jian Zhou,Mairead Reidy,Ciaran O’Reilly,Dilip V. Jarikote,Arvind Negi,Afshin Samali,Eva Szegezdi,Paul V. Murphy +7 more
TL;DR: A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide.
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Primetime Patriotism: News Media and the Securitization of Iraq
TL;DR: This paper argued that the Iraq War was an example of successful securitization and examined the role of the US news media in supporting the government's push for war in the context of heightened national feeling and patriotism after the events of 9/11.