G
Gunter Fingerle-Rowson
Researcher at North Shore-LIJ Health System
Publications - 29
Citations - 3901
Gunter Fingerle-Rowson is an academic researcher from North Shore-LIJ Health System. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 25, co-authored 29 publications receiving 3586 citations. Previous affiliations of Gunter Fingerle-Rowson include Ludwig Maximilian University of Munich & University of Cologne.
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Journal ArticleDOI
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen,Regina M. Krohn,Hongqi Lue,Julia L. Gregory,Alma Zernecke,Rory R. Koenen,Manfred Dewor,Ivan T. Georgiev,Andreas Schober,Lin Leng,Teake Kooistra,Gunter Fingerle-Rowson,Pietro Ghezzi,Robert Kleemann,Shaun R. McColl,Richard Bucala,Michael J. Hickey,Christian Weber +17 more
TL;DR: Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition and displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.
Journal ArticleDOI
Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response
Robert A. Mitchell,Hong Liao,Jason Chesney,Gunter Fingerle-Rowson,John A. Baugh,John R. David,Richard Bucala +6 more
TL;DR: Macrophage migration inhibitory factor (MIF), a product of activated macrophages, sustains macrophage survival and function by suppressing activation-induced, p53-dependent apoptosis and suggests new approaches for the modulation of innate immune responses.
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Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity
Hongqi Lue,Michael Thiele,J Franz,Edgar Dahl,Stefanie Speckgens,Lin Leng,Gunter Fingerle-Rowson,R Bucala,Bernhard Lüscher,Jürgen Bernhagen +9 more
TL;DR: MIF can directly promote cell survival through activation of the PI3K/Akt pathway and this effect is critical for tumor cell survival.
Journal ArticleDOI
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
Gunter Fingerle-Rowson,Oleksi Petrenko,Christine N. Metz,Thomas G. Forsthuber,Robert A. Mitchell,R. Huss,Ute M. Moll,Werner Müller,Richard Bucala +8 more
TL;DR: The data provide direct genetic evidence for a functional link between MIF and the p53 tumor suppressor and indicate an important and previously unappreciated role for MIF in carcinogenesis.
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Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity.
Hongqi Lue,Aphrodite Kapurniotu,Gunter Fingerle-Rowson,Thierry Roger,Lin Leng,Michael Thiele,Thierry Calandra,Richard Bucala,Jürgen Bernhagen +8 more
TL;DR: A novel MIF-driven signalling pathway and an intricate regulatory system involving extra- and possibly intracellular MIF, and which likely critically participates in controlling cell proliferation and survival is unravelled.