다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

I wish for you, with your newfound, immense skill in protein structure analysis, to consider α/β proteins. We shall consider TIM barrels, Rossmann folds, TOPRIM domains, ATPases, and kinases. Many more examples are available than we shall cover.

α/β Proteins

Surfactant-free oil-in-water emulsions prepared with temperature and pH sensitive poly(N-isopropylacrylamide)(PNIPAM) microgel particles offer unprecedented control of emulsion stability.

https://absimage.aps.org/image/MAR06/MWS_MAR06-2005-004393.pdf

Novel emulsions stabilized by pH and temperature sensitive microgels

https://hal.archives-ouvertes.fr/hal-02330281/document

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications.

Background Many biologically active and functional components are chemically unstable, and exhibit variable water/oil solubility, which reduce their bioavailability and efficacy. Therefore, the development and application of edible emulsion-based delivery systems for these compounds using food-grade materials would be extremely beneficial to the food industry. Recently, particle-stabilized emulsions (i.e., Pickering emulsions) have attracted significant attention from the scientific community owing to their surfactant-free character. Scope and approach This Review summarizes the recent applications of Pickering emulsions stabilized by food-grade particles for the encapsulation and delivery of lipophilic and hydrophilic bioactives. Firstly, the beneficial features of Pickering emulsions and their potential use for targeted delivery of bioactives are discussed. Next, different designs of Pickering emulsion-based delivery system (PEDS) and their performance in bioactives delivery are highlighted. Finally, the challenges and opportunities for future research are addressed. Key findings and conclusions Particles derived from proteins, polysaccharides, and lipids have received considerable research interest owing to their intrinsic biochemical properties that enable the development of PEDS that can improve the stability and delivery of bioactives. Different types of PEDS (i.e., O/W or W/O single emulsions, O/W/O or W/O/W double emulsions, emulgel, high internal phase emulsion, and microcapsules) have been developed and studied as versatile tools for encapsulation of both lipophilic and hydrophilic bioactives. Future research should focus on the elucidation of the release mechanism of bioactives from PEDS and the evaluation of the compatibility of PEDS with real food systems, as well as the efficacy and safety of PEDS using in vivo model. Development of PEDS in non-liquid state should also be a focus for future research in order to bridge the gap between lab and market.

Food-grade Pickering emulsions for encapsulation and delivery of bioactives

Pickering emulsions were formulated using biodegradable and biocompatible poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) prepared without surfactants or any other polymer than PLGA. A pharmaceutical and cosmetic oil (Miglyol) was chosen as the oil phase at a ratio of 10% w/w. These emulsions were then compared with emulsions using the same oil but formulated with well-described PLGA-poly(vinyl alcohol) (PVA) NPs, i.e., with PVA as NP stabilizers. Strikingly, the emulsions demonstrated very different structures at macroscopic, microscopic, and interfacial scales, depending on the type of NPs used. Indeed, the emulsion layer was significantly thicker when using PLGA NPs rather than PLGA-PVA NPs. This was attributed to the formation and coexistence of multiple water-in-oil-in-water (W/O/W) and simple oil-in-water (O/W) droplets, using a single step of emulsification, whereas simple O/W emulsions were obtained with PLGA-PVA NPs. The latter NPs were more hydrophilic than bare PLGA NPs because of the ...

/pdf/bare-and-sterically-stabilized-plga-nanoparticles-for-the-51fy452oiw.pdf

Claire Albert

Papers

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications.

Bare and Sterically Stabilized PLGA Nanoparticles for the Stabilization of Pickering Emulsions.

Tuning morphology of Pickering emulsions stabilised by biodegradable PLGA nanoparticles: How PLGA characteristics influence emulsion properties.

Pickering Emulsions Stabilized With Biodegradable Nanoparticles For The Co-Encapsulation Of Two Active Pharmaceutical Ingredients.