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Claire M. Weekley
Researcher at University of Adelaide
Publications - 16
Citations - 1053
Claire M. Weekley is an academic researcher from University of Adelaide. The author has contributed to research in topics: Selenium & Kidney metabolism. The author has an hindex of 13, co-authored 15 publications receiving 819 citations. Previous affiliations of Claire M. Weekley include University of Chicago & Howard Hughes Medical Institute.
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Journal ArticleDOI
Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease
Claire M. Weekley,Hugh H. Harris +1 more
TL;DR: It is concluded that dietary selenium compounds should be considered prodrugs, whose biological activity will depend on the activity of the various metabolic pathways in, and the redox status of, cells and tissues.
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Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells
Jade B. Aitken,Jade B. Aitken,Jade B. Aitken,Sumy Antony,Sumy Antony,Claire M. Weekley,Barry Lai,Leone Spiccia,Hugh H. Harris +8 more
TL;DR: X-ray fluorescence imaging was used to reveal the intracellular distribution of Ru in single human cells treated with KP1019, showing Ru localised in both cytosol and in the nuclear region, supporting the proposition that its activity is exerted through a membrane-binding mechanism.
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Metabolism of selenite in human lung cancer cells: X-ray absorption and fluorescence studies
Claire M. Weekley,Jade B. Aitken,Stefan Vogt,Lydia Finney,David J. Paterson,Martin D. de Jonge,Daryl L. Howard,Paul K. Witting,Ian F. Musgrave,Hugh H. Harris +9 more
TL;DR: The change in speciation from the selenol, selenocysteine, to the diselenide,selenocystine, is indicative of a change in the redox status of the cells to a more oxidizing environment, likely brought about by metabolites of selenite.
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Developing drugs targeting transition metal homeostasis.
Claire M. Weekley,Chuan He +1 more
TL;DR: This review presents recent highlights in the development of chelators and ionophores for the treatment of cancer and neurodegenerative disease and considers the emergence of metal regulatory factor 1 as a drug target in diseases where it mediates zinc-induced signalling cascades leading to pathogenesis.
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Selenium metabolism in cancer cells: The combined application of XAS and XFM techniques to the problem of selenium speciation in biological systems
TL;DR: A top-down approach to selenium speciation in human lung cancer cells that aims to link the speciation and distribution of selenum to its biological activity using a combination of X-ray absorption spectroscopy (XAS) andX-ray fluorescence microscopy ( XFM).