C
Claire Y. Ma
Researcher at University of Cambridge
Publications - 4
Citations - 105
Claire Y. Ma is an academic researcher from University of Cambridge. The author has contributed to research in topics: Cytotoxic T cell & T-cell receptor. The author has an hindex of 2, co-authored 4 publications receiving 49 citations.
Papers
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Journal ArticleDOI
PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.
Christian M. Gawden-Bone,Gordon L. Frazer,Arianne C. Richard,Claire Y. Ma,Katharina Strege,Gillian M. Griffiths +5 more
TL;DR: During immune synapse formation, rapid depletion of PIP5K at the synapse triggers subsequent changes in membrane composition and actin dynamics to establish a zone of localized granule secretion.
Journal ArticleDOI
Mitochondrial translation is required for sustained killing by cytotoxic T cells
Miriam Lisci,Philippa R. Barton,Lyra O. Randzavola,Claire Y. Ma,Julia M. Marchingo,Doreen A. Cantrell,Vincent Paupe,Julien Prudent,Jane C. Stinchcombe,Gillian M. Griffiths +9 more
TL;DR: T cell receptor activation of naive CD8+ T lymphocyte initiates their maturation into effector cytotoxic T lymphocytes (CTLs), which can kill cancer and virally infected cells.
Journal ArticleDOI
Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling.
Claire Y. Ma,John C. Marioni,John C. Marioni,John C. Marioni,Gillian M. Griffiths,Arianne C. Richard +5 more
TL;DR: It is found that stimulation strength dictates the rate with which cells initiate signalling through this network, suggesting that TCR-induced signalling results in a coordinated activation program, modulated in rate but not organization by stimulation strength.
Journal ArticleDOI
Staggered starts in the race to T cell activation.
TL;DR: In this paper, a probabilistic model was proposed to tune the response of T lymphocytes to different strengths of stimulation, which allowed activating T cells to achieve a wide range of population responses.