G
Gordon L. Frazer
Researcher at University of Cambridge
Publications - 8
Citations - 585
Gordon L. Frazer is an academic researcher from University of Cambridge. The author has contributed to research in topics: Immune system & Immunological synapse. The author has an hindex of 5, co-authored 8 publications receiving 323 citations.
Papers
More filters
Journal ArticleDOI
Spatiotemporal immune zonation of the human kidney
Benjamin J. Stewart,Benjamin J. Stewart,Benjamin J. Stewart,John R. Ferdinand,Matthew D. Young,Thomas J. Mitchell,Thomas J. Mitchell,Thomas J. Mitchell,Kevin W. Loudon,Kevin W. Loudon,Alexandra M. Riding,Alexandra M. Riding,Nathan Richoz,Gordon L. Frazer,Joy Ursula Lauren Staniforth,Felipe A. Vieira Braga,Rachel A. Botting,Dorin-Mirel Popescu,Roser Vento-Tormo,Emily Stephenson,Alex Cagan,Sarah J. Farndon,Sarah J. Farndon,Sarah J. Farndon,Krzysztof Polanski,Mirjana Efremova,Kile Green,Martin Del Castillo Velasco-Herrera,Charlotte Guzzo,Grace Collord,Grace Collord,Grace Collord,Lira Mamanova,Tevita Aho,James N. Armitage,Antony C. P. Riddick,Imran Mushtaq,Stephen Farrell,Dyanne Rampling,James Nicholson,James Nicholson,Andrew Filby,Johanna Burge,Steven Lisgo,Susan Lindsay,Marc Bajénoff,Anne Y. Warren,Grant D. Stewart,Grant D. Stewart,Neil J. Sebire,Neil J. Sebire,Nicholas Coleman,Nicholas Coleman,Muzlifah Haniffa,Muzlifah Haniffa,Sarah A. Teichmann,Sarah A. Teichmann,Sam Behjati,Sam Behjati,Sam Behjati,Menna R. Clatworthy,Menna R. Clatworthy,Menna R. Clatworthy +62 more
TL;DR: This study provides a global overview of how the immune landscape of the human kidney is zonated to counter the dominant immunological challenge.
Journal ArticleDOI
Gut-educated IgA plasma cells defend the meningeal venous sinuses.
Zachary Fitzpatrick,Gordon L. Frazer,Ashley Ferro,Simon Clare,Nicolas Bouladoux,John R. Ferdinand,Zewen K. Tuong,Zewen K. Tuong,María Luciana Negro-Demontel,Nitin Kumar,Ondrej Suchanek,Tamara Tajsic,Katherine Harcourt,Kirsten M. Scott,Rachel Bashford-Rogers,Adel Helmy,Daniel S. Reich,Yasmine Belkaid,Trevor D. Lawley,Dorian B. McGavern,Menna R. Clatworthy,Menna R. Clatworthy +21 more
TL;DR: It is shown that, during homeostasis, the mouse and human meninges contain IgA-secreting plasma cells, which are essential for defending the central nervous system at this vulnerable venous barrier surface.
Journal ArticleDOI
Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence
Brian J. Ferguson,Brian J. Ferguson,Camilla T. O. Benfield,Camilla T. O. Benfield,Hongwei Ren,Hongwei Ren,Vivian H. Lee,Gordon L. Frazer,Pavla Strnadova,Pavla Strnadova,Rebecca P. Sumner,Rebecca P. Sumner,Geoffrey L. Smith,Geoffrey L. Smith +13 more
TL;DR: The N2 protein is an intracellular virulence factor that inhibits IRF3 activity in the nucleus that is expressed early during infection and inhibits the activation of interferon regulatory factor (IRF)3.
Journal ArticleDOI
The cytotoxic T lymphocyte immune synapse at a glance.
TL;DR: The different steps that reveal the specialised mechanisms used to focus secretion at the CTL immune synapse and allow CTLs to be such efficient and precise serial killers are illustrated.
Journal ArticleDOI
PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.
Christian M. Gawden-Bone,Gordon L. Frazer,Arianne C. Richard,Claire Y. Ma,Katharina Strege,Gillian M. Griffiths +5 more
TL;DR: During immune synapse formation, rapid depletion of PIP5K at the synapse triggers subsequent changes in membrane composition and actin dynamics to establish a zone of localized granule secretion.