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Clare F. Megarity
Researcher at University of Oxford
Publications - 29
Citations - 640
Clare F. Megarity is an academic researcher from University of Oxford. The author has contributed to research in topics: Cooperativity & Quinone oxidoreductase. The author has an hindex of 13, co-authored 26 publications receiving 412 citations. Previous affiliations of Clare F. Megarity include Queen's University Belfast.
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Journal ArticleDOI
Transfer of photosynthetic NADP+/NADPH recycling activity to a porous metal oxide for highly specific, electrochemically-driven organic synthesis.
Bhavin Siritanaratkul,Clare F. Megarity,Thomas G. Roberts,Thomas O. M. Samuels,Martin Winkler,Jamie H. Warner,Thomas Happe,Fraser A. Armstrong +7 more
TL;DR: A bio-hybrid material has been discovered, which offers a new direction for fast, specific enzyme-catalyzed organic synthesis.
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FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1
TL;DR: The data suggest that the main molecular mechanisms associated with these cancer-related variants are their low binding affinity for FAD and/or kinetic instability and pharmacological chaperones may be useful in the treatment of patients bearing these polymorphisms.
Journal ArticleDOI
Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores.
Clare F. Megarity,Bhavin Siritanaratkul,Rachel S. Heath,Lei Wan,Giorgio Morello,Sarah R. FitzPatrick,Rosalind L. Booth,Adam J. Sills,Alex W. Robertson,Jamie H. Warner,Nicholas J. Turner,Fraser A. Armstrong +11 more
TL;DR: In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse.
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NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places.
TL;DR: NAD(P)H quinone oxidoreductase 1 (NQO1) catalyses the two electron reduction of quinones and a wide range of other organic compounds, and is implicated in cancer.
Journal ArticleDOI
The value of enzymes in solar fuels research - efficient electrocatalysts through evolution.
Rhiannon M. Evans,Bhavin Siritanaratkul,Clare F. Megarity,Kavita Pandey,Thomas F. Esterle,Selina Badiani,Fraser A. Armstrong +6 more
TL;DR: Experiments reveal the fleeting existence of reversible four-electron O2 reduction and water oxidation by 'blue' Cu oxidases, another reaction of great importance in realising a future based on renewable energy.