R
Rachel S. Heath
Researcher at University of Manchester
Publications - 27
Citations - 730
Rachel S. Heath is an academic researcher from University of Manchester. The author has contributed to research in topics: Chemistry & Biocatalysis. The author has an hindex of 12, co-authored 20 publications receiving 423 citations.
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Journal ArticleDOI
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination.
James R. Marshall,Peiyuan Yao,Peiyuan Yao,Sarah L. Montgomery,James Finnigan,Thomas W. Thorpe,Ryan B. Palmer,Juan Mangas-Sanchez,Richard A. M. Duncan,Rachel S. Heath,Kirsty M. Graham,Darren J. Cook,Simon J. Charnock,Nicholas J. Turner +13 more
TL;DR: In this paper, the authors report the discovery of over 300 new imine reductases and the production of a large (384 enzymes) and sequence-diverse panel of imine reduction enzymes available for screening.
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Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades.
Jeremy I. Ramsden,Rachel S. Heath,Sasha R. Derrington,Sarah L. Montgomery,Juan Mangas-Sanchez,Keith R. Mulholland,Nicholas J. Turner +6 more
TL;DR: Two complementary one-pot systems in which the reductive aminase (RedAm) from Aspergillus oryzae is combined with either a 1° alcohol/alcohol oxidase (AO) or carboxylic acid/carboxy Lic acid reductase (CAR) to affect N-alkylation reactions are reported.
Journal ArticleDOI
A generic platform for the immobilisation of engineered biocatalysts
Matthew P. Thompson,Sasha R. Derrington,Rachel S. Heath,Joanne L. Porter,Juan Mangas-Sanchez,Paul N. Devine,Matthew D. Truppo,Nicholas J. Turner +7 more
TL;DR: Challenges facing both academic and industrial applications such as enzyme stability, multistep reactions and reactions in continuous flow are focussed on.
Journal ArticleDOI
Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles
TL;DR: A novel amine oxidase (AO)/imine reductase (IRED) system was developed for the deracemization of racemic amines to yield the (S)‐amines in high yields and enantiomeric excess values.
Journal ArticleDOI
Development of an R-Selective Amine Oxidase with Broad Substrate Specificity and High Enantioselectivity
TL;DR: The development of an enantiocomplementary R‐selective amine oxidase based on 6‐hydroxy‐D‐nicotine oxidase (6‐HDNO) with broadened substrate scope and high enantioselectivity is reported.