Claudia Gerri

TL;DR: It is shown that egfl7 mutants are less sensitive than their wild-type siblings to Egfl7 knockdown, arguing against residual protein function in the mutants or significant off-target effects of the morpholinos when used at a moderate dose, and the activation of a compensatory network to buffer against deleterious mutations was not observed after translational or transcriptional knockdown.

TL;DR: Transcriptional adaptation, a genetic compensation process by which organisms respond to mutations by upregulating related genes, is triggered by mRNA decay and involves a sequence-dependent mechanism.

TL;DR: Comparative analysis of human,cow and mouse embryos shows that a mechanism involving atypical protein kinase C initiates the trophectoderm program during the morula stage in these three species and suggests that a similar mechanism initiates a TE program in human, cow and mouse babies.

TL;DR: Genetic evidence is provided that Hif-1α regulates interactions between macrophages and endothelial cells starting with the mobilization of macrophage mobilization from the aorta-gonad-mesonephros (AGM) region.

TL;DR: The authors use a bioinformatics approach to identify the role of IGF1 in human embryo development, and from this, propose a culture medium with IGF1 together with Activin to sustain hESCs in the absence of FGF.