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Nana Fukuda
Researcher at Max Planck Society
Publications - 9
Citations - 926
Nana Fukuda is an academic researcher from Max Planck Society. The author has contributed to research in topics: Zebrafish & Gene. The author has an hindex of 5, co-authored 8 publications receiving 656 citations.
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Journal ArticleDOI
Genetic compensation triggered by mutant mRNA degradation
Mohamed A. El-Brolosy,Zacharias Kontarakis,Andrea Rossi,Andrea Rossi,Carsten Kuenne,Stefan Günther,Nana Fukuda,Khrievono Kikhi,Giulia L. M. Boezio,Carter M. Takacs,Carter M. Takacs,Shih-Lei Lai,Shih-Lei Lai,Ryuichi Fukuda,Claudia Gerri,Claudia Gerri,Antonio J. Giraldez,Didier Y.R. Stainier +17 more
TL;DR: Transcriptional adaptation, a genetic compensation process by which organisms respond to mutations by upregulating related genes, is triggered by mRNA decay and involves a sequence-dependent mechanism.
Journal ArticleDOI
Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification
Sven Reischauer,Oliver A. Stone,Alethia Villasenor,Neil C. Chi,Neil C. Chi,Suk-Won Jin,Marcel Martin,Miler T. Lee,Nana Fukuda,Michele Marass,Alec D. Witty,Ian T. Fiddes,Taiyi Kuo,Won-Suk Chung,Sherveen Salek,Robert Lerrigo,Jessica Alsiö,Shujun Luo,Dominika Tworus,Sruthy Maria Augustine,Sophie Mucenieks,Björn Nystedt,Antonio J. Giraldez,Gary P. Schroth,Olov Andersson,Didier Y.R. Stainier +25 more
TL;DR: The isolation of the cloche gene was succeeded in isolating and it was discovered that it encodes a PAS-domain-containing bHLH transcription factor, and that it is expressed in a highly specific spatiotemporal pattern starting during late gastrulation.
Journal ArticleDOI
HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
Sébastien Gauvrit,Alethia Villasenor,Boris Strilic,Philip Kitchen,Michelle M. Collins,Rubén Marín-Juez,Stefan Guenther,Hans-Martin Maischein,Nana Fukuda,Maurice A. Canham,Joshua M. Brickman,Clifford W. Bogue,Padma-Sheela Jayaraman,Didier Y.R. Stainier +13 more
TL;DR: The authors show that the transcription factor hematopoietically expressed homeobox (HHEX) regulates VEGFC, FLT4 and PROX1 in fish and mammals during angiogenic sprouting and lymphatic formation.
Journal ArticleDOI
Genome-wide strategies reveal target genes of Npas4l associated with vascular development in zebrafish.
Michele Marass,Arica Beisaw,Claudia Gerri,Francesca Luzzani,Nana Fukuda,Stefan Günther,Carsten Kuenne,Sven Reischauer,Didier Y.R. Stainier +8 more
TL;DR: Multiple genome-wide approaches reveal that Npas4l functions as a master regulator by directly inducing a group of transcription factor genes that are crucial for hematoendothelial specification.
Posted ContentDOI
Genetic compensation is triggered by mutant mRNA degradation
Mohamed A. El-Brolosy,Andrea Rossi,Zacharias Kontarakis,Carsten Kuenne,Stefan Günther,Nana Fukuda,Carter M. Takacs,Shih-Lei Lai,Ryuichi Fukuda,Claudia Gerri,Khrievono Kikhi,Antonio J. Giraldez,Didier Y.R. Stainier +12 more
TL;DR: The role of the mRNA surveillance machinery in buffering against mutations by triggering the transcriptional upregulation of related genes is expanded, and the role of mutants that fail to transcribe the mutated gene do not show transcriptional adaptation.