Claudia Gidea

TL;DR: The presence of a functional ANG II-dependent pathway for apoptosis in human and rat AECs is demonstrated and a role for the ANG II receptor and ACE in the induction of AEC apoptosis is suggested in vivo.

TL;DR: Data indicate that the induction of A EC apoptosis by TNF‐α requires a functional renin/angiotensin system (RAS) in the target cell and suggest that therapeutic control of AEC apoptosis in response to TNF-α is feasible through pharmacologic manipulation of the local RAS.

TL;DR: The data suggest that the inhibitory actions of captopril on pulmonary fibrosis may be related to prevention of lung epithelial cell apoptosis.

TL;DR: Immunologic studies and differential kinetics of caspase activation suggest that Fas and TNF-α induce apoptosis in HCAEC by signaling pathways that are distinct but equal in potency.

TL;DR: The role of sex hormones on the pathophysiology of AHF is discussed, the clinical presentation, diagnostic evaluation and definitive therapies ofAHF in women with special attention to pregnancy, lactation, contraception and menopause are described, and areas of equipoise in the care of women with AHF are addressed.