F
Filio Billia
Researcher at University Health Network
Publications - 136
Citations - 4919
Filio Billia is an academic researcher from University Health Network. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 26, co-authored 91 publications receiving 3841 citations. Previous affiliations of Filio Billia include University of Toronto & Ottawa Hospital Research Institute.
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Journal ArticleDOI
Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice
Wen-Chen Yeh,Arda Shahinian,Daniel I Speiser,Janine Kraunus,Filio Billia,Andrew Wakeham,José Luis de la Pompa,David A. Ferrick,Betty Hum,Norman N. Iscove,Pamela S. Ohashi,Mike Rothe,David V. Goeddel,Tak W. Mak +13 more
TL;DR: Results suggest that TRAf2-independent pathways of NF-kappaB activation exist and that TRAF2 is required for an NF- kappaB-independent signal that protects against TNF-induced apoptosis.
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The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse
Razqallah Hakem,Razqallah Hakem,José Luis de la Pompa,José Luis de la Pompa,Christian Sirard,Christian Sirard,Rong Mo,Minna Woo,Minna Woo,Anne Hakem,Anne Hakem,Andrew Wakeham,Andrew Wakeham,Julia Potter,Julia Potter,Armin Reitmair,Armin Reitmair,Filio Billia,Eduardo Firpo,Chi-chung Hui,James M. Roberts,Janet Rossant,Janet Rossant,Tak W. Mak,Tak W. Mak +24 more
TL;DR: The death of Brca1(5-6) mutant embryos prior to gastrulation may be due to a failure of the proliferative burst required for the development of the different germ layers, and the fact that mutant blastocyst growth is grossly impaired in vitro.
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Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells
Gerard Brady,Filio Billia,Jennifer J. Knox,Trang Hoang,Ilan R. Kirsch,Evelyn B. Voura,Robert G. Hawley,Robert C. Cumming,Manuel Buchwald,Kathy Siminovitch,Neil G. Miyamoto,Guido Boehmelt,Norman N. Iscove +12 more
TL;DR: The results provide the first expression mapping of these genes that distinguishes between progenitors in different commitment states, generate new insights and predictions relevant to mechanism, and introduce a powerful set of tools for unravelling the genetic basis of lineage divergence.
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PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function
TL;DR: In vivo data demonstrate that PINK1 activity is crucial for postnatal myocardial development, through its role in maintaining mitochondrial function, and redox homeostasis in cardiomyocytes, and possesses a distinct, nonredundant function in the surveillance and maintenance of cardiac tissueHomeostasis.
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Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction
Victor Dayan,Gustavo Yannarelli,Filio Billia,Paola Filomeno,Xing-Hua Wang,John E. Davies,Armand Keating,Armand Keating +7 more
TL;DR: The data suggest a new mechanism for MSC-mediated enhancement of cardiac function, possibly via an IL-10 mediated switch from infiltration of pro-inflammatory to anti-inflammatory macrophages at the infarct site.