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Claudia Metz
Researcher at San Sebastián University
Publications - 18
Citations - 443
Claudia Metz is an academic researcher from San Sebastián University. The author has contributed to research in topics: Endosome & Galectin. The author has an hindex of 12, co-authored 18 publications receiving 363 citations. Previous affiliations of Claudia Metz include Pontifical Catholic University of Chile & University of Chile.
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Journal ArticleDOI
Anti–Ribosomal P Protein Autoantibodies From Patients With Neuropsychiatric Lupus Impair Memory in Mice
Marcela Bravo-Zehnder,Enrique M. Toledo,Fabián Segovia-Miranda,Felipe Serrano,María J Benito,Claudia Metz,Claudio Retamal,Alejandra R. Alvarez,Loreto Massardo,Nibaldo C. Inestrosa,Alfonso González +10 more
TL;DR: Whether anti‐ribosomal P (anti‐P) autoantibodies from patients with neuropsychiatric systemic lupus erythematosus (NPSLE) impair the function of hippocampal neurons that express the neuronal surface P antigen (NSPA) when accessing the brain via circulating blood is defined.
Journal ArticleDOI
Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1/2 activation supported by protein kinase A down-regulation.
Andrés Norambuena,Claudia Metz,Lucas Vicuña,Antonia Silva,Evelyn Pardo,Claudia Oyanadel,Loreto Massardo,Alfonso González,Andrea Soza +8 more
TL;DR: The results implicate Gal-8 as a novel T cell suppressive factor, which can be counterbalanced by function-blocking autoantibodies in autoimmunity.
Journal ArticleDOI
Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation
Loreto Massardo,Claudia Metz,Evelyn Pardo,Verónica Mezzano,M Babul,E Jarpa,Amador M. Guzmán,Sabine André,Herbert Kaltner,Hans-Joachim Gabius,Sergio Jacobelli,Alfonso González,Andrea Soza +12 more
TL;DR: The role of auto-antibodies in the pathogenesis of systemic lupus erythematosus (SLE) has not been completely defined by.
Journal ArticleDOI
Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimer's disease pathophysiology.
Francisca Cornejo,Marianne Vruwink,Claudia Metz,Claudia Metz,Paola Muñoz,Nicole Salgado,Joaquín Poblete,María Estela Andrés,Jaime Eugenín,Rommy von Bernhardi +9 more
TL;DR: The results indicate that reduced expression of SR-A can deregulate glial inflammatory response and potentiate Aβ accumulation, two mechanisms that could contribute to AD progression.
Journal Article
Increased expression of c-rel, from the NF-kappaB/Rel family, in T cells from patients with systemic lupus erythematosus.
Patricia V. Burgos,Claudia Metz,Paulina Bull,Roxana Pincheira,Loreto Massardo,C. Errazuriz,María Rosa Bono,Sergio Jacobelli,Alfonso González +8 more
TL;DR: The data suggest that T cells from patients with SLE possess altered regulatory mechanisms of c-rel expression and nuclear import that might potentially determine conditions for developing autoimmunity.