F
Fabián Segovia-Miranda
Researcher at Max Planck Society
Publications - 24
Citations - 1443
Fabián Segovia-Miranda is an academic researcher from Max Planck Society. The author has contributed to research in topics: Liquid crystal & Microscopy. The author has an hindex of 10, co-authored 20 publications receiving 856 citations. Previous affiliations of Fabián Segovia-Miranda include Pontifical Catholic University of Chile.
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Journal ArticleDOI
Content-aware image restoration: pushing the limits of fluorescence microscopy.
Martin Weigert,Uwe Schmidt,Tobias Boothe,Andreas Müller,Alexandr Dibrov,Akanksha Jain,Benjamin Wilhelm,Deborah Schmidt,Coleman Broaddus,Siân Culley,Siân Culley,Mauricio Rocha-Martins,Fabián Segovia-Miranda,Caren Norden,Ricardo Henriques,Ricardo Henriques,Marino Zerial,Michele Solimena,Jochen C. Rink,Pavel Tomancak,Loic Royer,Florian Jug,Eugene W. Myers,Eugene W. Myers +23 more
TL;DR: This work shows how content-aware image restoration based on deep learning extends the range of biological phenomena observable by microscopy by bypassing the trade-offs between imaging speed, resolution, and maximal light exposure that limit fluorescence imaging to enable discovery.
Posted ContentDOI
Content-Aware Image Restoration: Pushing the Limits of Fluorescence Microscopy
Martin Weigert,Uwe Schmidt,Tobias Boothe,Andreas Müller,Alexandr Dibrov,Akanksha Jain,Benjamin Wilhelm,Deborah Schmidt,Coleman Broaddus,Siân Culley,Mauricio Rocha-Martins,Fabián Segovia-Miranda,Caren Norden,Ricardo Henriques,Marino Zerial,Michele Solimena,Jochen C. Rink,Pavel Tomancak,Loic Royer,Florian Jug,Eugene W. Myers,Eugene W. Myers +21 more
TL;DR: This work shows how deep learning enables biological observations beyond the physical limitations of microscopes, and illustrates how microscopy images can be restored even if 60-fold fewer photons are used during acquisition.
Journal ArticleDOI
A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture
Hernán Morales-Navarrete,Fabián Segovia-Miranda,Piotr Klukowski,Kirstin Meyer,Hidenori Nonaka,Giovanni Marsico,Mikhail Chernykh,Alexander Kalaidzidis,Marino Zerial,Yannis Kalaidzidis,Yannis Kalaidzidis +10 more
TL;DR: A flexible pipeline for the multi-scale reconstruction and quantitative morphological analysis of tissue architecture from microscopy images is designed and an unexpected zonation pattern of hepatocytes with different size, nuclei and DNA content is uncovered, thus revealing new features of liver tissue organization.
Journal ArticleDOI
Anti–Ribosomal P Protein Autoantibodies From Patients With Neuropsychiatric Lupus Impair Memory in Mice
Marcela Bravo-Zehnder,Enrique M. Toledo,Fabián Segovia-Miranda,Felipe Serrano,María J Benito,Claudia Metz,Claudio Retamal,Alejandra R. Alvarez,Loreto Massardo,Nibaldo C. Inestrosa,Alfonso González +10 more
TL;DR: Whether anti‐ribosomal P (anti‐P) autoantibodies from patients with neuropsychiatric systemic lupus erythematosus (NPSLE) impair the function of hippocampal neurons that express the neuronal surface P antigen (NSPA) when accessing the brain via circulating blood is defined.
Journal ArticleDOI
A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule
Kirstin Meyer,Oleksandr Ostrenko,Georgios Bourantas,Georgios Bourantas,Georgios Bourantas,Hernán Morales-Navarrete,Natalie Porat-Shliom,Fabián Segovia-Miranda,Hidenori Nonaka,Ali Ghaemi,Jean-Marc Verbavatz,Lutz Brusch,Ivo F. Sbalzarini,Ivo F. Sbalzarini,Yannis Kalaidzidis,Yannis Kalaidzidis,Roberto Weigert,Marino Zerial,Marino Zerial +18 more
TL;DR: A predictive 3D multi-scale model that simulates fluid dynamic properties successively from the subcellular to the tissue level is developed that can be applied to functionally characterize liver diseases and quantitatively estimate biliary transport upon drug-induced liver injury.