P
Patricia V. Burgos
Researcher at San Sebastián University
Publications - 45
Citations - 1739
Patricia V. Burgos is an academic researcher from San Sebastián University. The author has contributed to research in topics: Endosome & Golgi apparatus. The author has an hindex of 23, co-authored 36 publications receiving 1470 citations. Previous affiliations of Patricia V. Burgos include Millennium Institute & Austral University of Chile.
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Journal ArticleDOI
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.
Patricia V. Burgos,Gonzalo A. Mardones,Adriana L. Rojas,Luis L. P. daSilva,Yogikala Prabhu,James H. Hurley,Juan S. Bonifacino +6 more
TL;DR: It is demonstrated that APP and AP-4 engage in a distinct type of signal-adaptor interaction that mediates transport of APP from the trans-Golgi network (TGN) to endosomes, thereby reducing amyloidogenic processing of the protein.
Journal ArticleDOI
Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis.
Soledad Matus,Patricia V. Burgos,Marcela Bravo-Zehnder,Regine Kraft,Omar Porras,Paula Farías,L. Felipe Barros,Fernando Torrealba,Loreto Massardo,Sergio Jacobelli,Alfonso González +10 more
TL;DR: It is shown that anti-P antibodies recognize a new integral membrane protein of the neuronal cell surface that is preferentially distributed in areas involved in memory, cognition, and emotion and provides a molecular target for future exploration of this and other psychiatric diseases.
Journal ArticleDOI
Exosomes as Novel Regulators of Adult Neurogenic Niches
Luis Federico Bátiz,Maite A. Castro,Patricia V. Burgos,Zahady D. Velásquez,Rosa I. Muñoz,Carlos Lafourcade,Paulina Troncoso-Escudero,Ursula Wyneken +7 more
TL;DR: This review focuses on the current knowledge regarding the functional relationship between cellular and extracellular components of the adult SVZ and SGZ neurogenic niches, and the growing evidence that supports the potential role of exosomes in the physiology and pathology of adult neurogenesis.
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Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes
Vincent Popoff,Gonzalo A. Mardones,Siau-Kun Bai,Siau-Kun Bai,Valérie Chambon,Valérie Chambon,Danièle Tenza,Danièle Tenza,Patricia V. Burgos,Anbing Shi,Philippe Benaroch,Sylvie Urbé,Christophe Lamaze,Christophe Lamaze,Barth D. Grant,Graça Raposo,Graça Raposo,Ludger Johannes,Ludger Johannes +18 more
TL;DR: A model according to which the functions in retrograde sorting on early endosomes of SNX1/retromer and clathrin are articulated by RME‐8, and possibly also by Hrs is suggested.
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Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells
TL;DR: The results are consistent with a scenario in which cholesterol-based rafts promote internalization and basolateral recycling of internalized SR-BI whereas a PKA pool sensitive to cholesterol depletion mediatesSR-BI transcytosis, and may provide an additional mechanism to control cholesterol homeostasis.