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Andrés Norambuena
Researcher at University of Virginia
Publications - 24
Citations - 768
Andrés Norambuena is an academic researcher from University of Virginia. The author has contributed to research in topics: Signal transduction & Lipid raft. The author has an hindex of 14, co-authored 23 publications receiving 685 citations. Previous affiliations of Andrés Norambuena include Pontifical Catholic University of Chile.
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Journal ArticleDOI
Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease
Matthew E. Seward,Eric Swanson,Andrés Norambuena,Anja Reimann,J. Nicholas Cochran,Rong Li,Erik D. Roberson,George S. Bloom +7 more
TL;DR: It is reported that this ectopic cell cycle re-entry (CCR) requires soluble amyloid-&b gr; (A&bgr;) and tau, the respective building blocks of the insoluble plaques and tangles that accumulate in AD brain.
Journal ArticleDOI
Apical sorting of a voltage- and Ca2+-activated K+ channel alpha -subunit in Madin-Darby canine kidney cells is independent of N-glycosylation.
Marcela Bravo-Zehnder,Patricio Orio,Andrés Norambuena,Martin Wallner,Pratap Meera,Ligia Toro,Ramon Latorre,Alfonso González +7 more
TL;DR: The evidence indicates that the hSlo protein possesses intrinsic information for transport to the apical cell surface through a mechanism that may involve association with lipid rafts and that is independent of glycosylation of the channel itself or an associated protein.
Journal ArticleDOI
RalA-Exocyst Complex Regulates Integrin-Dependent Membrane Raft Exocytosis and Growth Signaling
Nagaraj Balasubramanian,Jeremy A. Meier,David W. Scott,Andrés Norambuena,Michael A. White,Martin A. Schwartz +5 more
TL;DR: The results identify RalA as a key determinant of integrin-dependent membrane raft trafficking and regulation of growth signaling and provide a new link between integrin signaling and cancer.
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Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1/2 activation supported by protein kinase A down-regulation.
Andrés Norambuena,Claudia Metz,Lucas Vicuña,Antonia Silva,Evelyn Pardo,Claudia Oyanadel,Loreto Massardo,Alfonso González,Andrea Soza +8 more
TL;DR: The results implicate Gal-8 as a novel T cell suppressive factor, which can be counterbalanced by function-blocking autoantibodies in autoimmunity.
Journal ArticleDOI
mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease
Andrés Norambuena,Horst Wallrabe,Lloyd McMahon,Antonia Silva,Eric Swanson,Shahzad S. Khan,Daniel Baerthlein,Erin Kodis,Salvatore Oddo,James Mandell,George S. Bloom +10 more
TL;DR: The data indicate that the decreased insulin signaling provoked by AβOs unleashes their toxic potential to cause neuronal CCR, and by extension, neuron death, and that CCR can be prevented by insulin‐stimulated activation of lysosomal mTORC1.