C
Claudio Counoupas
Researcher at University of Sydney
Publications - 36
Citations - 643
Claudio Counoupas is an academic researcher from University of Sydney. The author has contributed to research in topics: Vaccination & Mycobacterium tuberculosis. The author has an hindex of 10, co-authored 27 publications receiving 466 citations. Previous affiliations of Claudio Counoupas include Centenary Institute & University of Pisa.
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Journal ArticleDOI
Direct Binding of Human NK Cell Natural Cytotoxicity Receptor NKp44 to the Surfaces of Mycobacteria and Other Bacteria
Semih Esin,Giovanna Batoni,Claudio Counoupas,Annarita Stringaro,Franca Lisa Brancatisano,Marisa Colone,Giuseppantonio Maisetta,Walter Florio,Giuseppe Arancia,Mario Campa +9 more
TL;DR: Results obtained indicate, for the first time, that at least one member of the NCR family (NKp44) may be involved in the direct recognition of bacterial pathogens by human NK cells.
Journal ArticleDOI
Interaction of Mycobacterium tuberculosis Cell Wall Components with the Human Natural Killer Cell Receptors NKp44 and Toll-Like Receptor 2
Semih Esin,Claudio Counoupas,Anna Aulicino,Franca Lisa Brancatisano,Giuseppantonio Maisetta,Daria Bottai,M. Di Luca,Walter Florio,Mario Campa,Giovanna Batoni +9 more
TL;DR: Results provide evidence that components abundant in mycobacterial cell wall are able to interact with NKp44 (AG, MA) and TLR‐2 (PG), respectively, and promote activation of resting NK cells and IFN‐γ production, and could play a secondary role in maintaining cell activation.
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A composite fibrin-based scaffold for controlled delivery of bioactive pro-angiogenetic growth factors
Enrica Briganti,Dario Spiller,Chiara Mirtelli,Silvia Kull,Claudio Counoupas,Paola Losi,Sonia Senesi,Rossella Di Stefano,Giorgio Soldani +8 more
TL;DR: The new composite scaffolds, once implanted, providing a co-localization and temporal distribution of bioactive VEGF and bFGF in addition to good mechanical properties, may be useful to stimulate new vessels formation in ischemic tissues.
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Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection.
Claudio Counoupas,Claudio Counoupas,Rachel Pinto,Rachel Pinto,Gayathri Nagalingam,Gayathri Nagalingam,Warwick J. Britton,Warwick J. Britton,Nikolai Petrovsky,Nikolai Petrovsky,James A. Triccas,James A. Triccas +11 more
TL;DR: If Advax displays broad applicability against important human pathogens by assessing protective immunity against infection with M. tuberculosis, CysVac2/AdvaxCpG is a strong candidate for further preclinical evaluation for progression to human trials.
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The ESX-5 Associated eccB5-eccC5 Locus Is Essential for Mycobacterium tuberculosis Viability
Mariagrazia Di Luca,Daria Bottai,Giovanna Batoni,Mickael Orgeur,Anna Aulicino,Claudio Counoupas,Mario Campa,Roland Brosch,Semih Esin +8 more
TL;DR: The characterization of two M. tuberculosis conditional mutant strains confirmed that the repression of eccB5-eccC5 genes is detrimental for growth of M.culosis both in vitro and in THP-1 human macrophage cell line, and revealed that both EccB5 and EccC5 are required for secretion of ESX-5 specific substrates, thus confirming that they are indeed components of the ESX -5 secretion machinery.