C
Claudio Ortenzi
Researcher at University of Macerata
Publications - 57
Citations - 1102
Claudio Ortenzi is an academic researcher from University of Macerata. The author has contributed to research in topics: Mating type & Sex pheromone. The author has an hindex of 21, co-authored 54 publications receiving 1021 citations. Previous affiliations of Claudio Ortenzi include University of Camerino.
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Journal ArticleDOI
Dysfunctional autophagy induced by the pro-apoptotic natural compound climacostol in tumour cells
Silvia Zecchini,Francesca Proietti Serafini,Elisabetta Catalani,Matteo Giovarelli,Marco Coazzoli,Ilaria Di Renzo,Clara De Palma,Cristiana Perrotta,Emilio Clementi,Federico Buonanno,Claudio Ortenzi,Enrico Marcantoni,Anna Rita Taddei,Simona Picchietti,Anna Maria Fausto,Davide Cervia +15 more
TL;DR: It is shown that climacostol potently and selectively impairs autophagy in multiple tumour cells that are committed to die by apoptosis, suggesting the efficacy of ciliate bioactive molecules to identify novel lead compounds in drug discovery and development.
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A cooperative model for receptor recognition and cell adhesion: evidence from the molecular packing in the 1.6-A crystal structure of the pheromone Er-1 from the ciliated protozoan Euplotes raikovi
M.S. Weiss,Daniel H. Anderson,Simona Raffioni,Ralph A. Bradshaw,Claudio Ortenzi,Pierangelo Luporini,David Eisenberg +6 more
TL;DR: In this model, strong pheromone-receptor binding emerges as a consequence of the cooperative utilization of several weak interactions, which offers an explanation for the results of binding studies and may also explain the adhesion between cells that occurs during mating.
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Nuclear Magnetic Resonance Solution Structure of the Pheromone Er-10 from the Ciliated Protozoan Euplotes raikovi
Larry R. Brown,S. Mronga,Ralph A. Bradshaw,Claudio Ortenzi,Pierangelo Luporini,Kurt Wüthrich +5 more
TL;DR: The three-dimensional structure in solution of the pheromone Er-10 from the ciliated protozoan Euplotes raikovi has been determined by nuclear magnetic resonance spectroscopy and shows an asymmetric charge distribution that results in a predominantly apolar surface on one side of the molecule.
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An integrated study of the species problem in the Euplotes crassus-minuta-vannus group
TL;DR: The overall results supported the validity of the three named species and showed that isozymic variations, in particular of amylases, malic enzyme, and malic dehydrogenase, were very restricted within conspecific strains and were great between non-conspecifics.
Journal Article
Ciliate Mating Types and Their Specific Protein Pheromones
TL;DR: The determination of a number of pheromone structures from species of Euplotes provided direct evidence that these cell typespecific signals are represented by families of homologous proteins, consistently with their genetic control through series of single-locus multiple alleles.