Ilaria Di Renzo

TL;DR: This is the first demonstration that endogenous NO system is a key mechanism through which TAMs protect tumor cells from chemotherapeutic drug-induced apoptosis and warrants further investigations as a means to identify new anti-cancer molecules capable of specifically inhibiting synt4 degradation.

TL;DR: It is shown that climacostol potently and selectively impairs autophagy in multiple tumour cells that are committed to die by apoptosis, suggesting the efficacy of ciliate bioactive molecules to identify novel lead compounds in drug discovery and development.

TL;DR: Observations revealed the antithetic role of apoptosis and autophagy, highlighting their equilibrium from which neuronal survival is likely to depend and suggest the crucial role covered by autophagic, which could be considered as a molecular target for DR neuroprotective treatment strategies.

TL;DR: The fact that A-SMase in melanomas affects mTOR-regulated autophagy and plays a central role in cisplatin efficacy encourages pre-clinical testing on the modulation of A- SMase levels/activity as possible novel anti-neoplastic strategy.

TL;DR: It is shown that autophagy is specifically required for neonatal myogenesis and muscle development in the neonatal phase, and a novel autophile-dependent pathway that regulates nSC behavior is identified.