Clayton T. Cuddington

TL;DR: The development of a polymeric based bi-layered capsule that could address challenges of maintaining bevacizumab at high concentrations over extended periods by extending the release over one year, thereby providing an effective platform enabling treatment of chronic vascular diseases.

TL;DR: This work implemented a controlled method of gas exchange and reagent addition that results in a more homogenous PolyhHb product and assessed how the hemoglobin scavenging protein haptoglobin (Hp) would interact with polymerized human hemoglobins molecules of varying size and quarternary state.

TL;DR: The generation of submicron-sized particles comprising myoglobin fused to the crystal-forming domain of Cry3Aa protein for the targeted delivery of oxygen to cancer cells suggest that the targeted Delivery of O2-bound myoglobin could be an effective approach to enhance the efficacy of radiotherapy.

TL;DR: Results suggest that targeting a specific Damköhler number may be beneficial for optimal hepatic HF bioreactor operation.

TL;DR: In this article, the authors investigated the responses to resuscitation from severe hemorrhagic shock (HS) after TBI in rats, using fresh blood, polymerized human hemoglobin (PolyhHb), and lactated Ringer's (LR).