Showing papers in "Bioconjugate Chemistry in 2020"

TL;DR: The current role of AFPs in biosensing and bioimaging is reviewed, with emphasize on NIR-II AFPs developed for biomedical applications, and the challenges and prospects ofAFPs are discussed by considering the clinical translation from bench to bedside.

TL;DR: Given the recent successes at overcoming the limitations of squaraine dyes, they show a high potential in biological imaging, photodynamic and photothermal therapies, and as molecular sensors.

TL;DR: This review will critically analyze the proposed mechanisms underlying SDT and overview how nanomedicines can complement and extend these mechanisms to deliver more efficacious SDT.

TL;DR: How particle stability, biodistribution, and targeting of LNPs can be influenced by the biological environment is addressed and the potential of exploiting the corona as a targeting strategy beyond the liver to develop next-generation gene therapies is examined.

TL;DR: The recent advances in molecular imaging achieved using novel AuNP structures, cell tracking using AuNP, targeted AuNP for cancer imaging, and activatable AuNP probes are summarized.

TL;DR: In this review, the recent progress developed on NIR fluorescence including inorganic molecules, small organic molecules and fluorescence proteins are summarized and the recent advanced beam shaped microscopy techniques to provide the options to combine with the emitters introduced previously are covered.

TL;DR: Nanoparticles-based smart dressings are being recently explored for bacteria detection and treatment, which enables an accurate assessment of bacterial infection and a more precise control of on-demand therapy.

TL;DR: This review will focus on the recent advances of degradable inorganic nanoparticles for cancer theranostics with highlighting the degradation mechanism, aiming to offer an in-depth understanding of degradation behavior and related biomedical applications.

TL;DR: Overall, the evidence is consistent with in vitro and in vivo results and indicates that the two dyes in the test series that accumulate in tumors and persist there (1-Cl and 5-Cl, true tumor-seeking dyes) do so as covalent albumin adducts trapped in tumor tissue via uptake by some cancer cells and via the enhanced permeability and retention (EPR) effect.

TL;DR: This article focuses on the recent progress of photothermal therapy based on tumor microenvironment remodeling, aiming to better guide the design of nanoparticles for cancer photo-immunotherapy.

TL;DR: The evaluation of cell proliferation and biochemical assay of this BMSC-laden 3D bioprinted hydrogel proved that it could ensure sufficient nutrient supply and great biochemical supportability in tissue engineering and holds a great promise as candidate for cartilage tissue regeneration.

TL;DR: This multifunctional nanosystem with cascade reactions could inhibit tumor growth and activate immune responses effectively and combine with anti-programmed death-ligand 1 (anti-PD-L1) checkpoint blockade therapy, distant tumor Growth and cancer metastasis were successfully suppressed.

TL;DR: A simple NIR-II emitting water-soluble system has been developed and applied in vitro and in vivo, and the fluorophore quickly accumulated in 2D and 3D cell cultures and rapidly reached the tumor in rodents, showing high Nir-II contrast for up to one week.

TL;DR: In this paper, a review summarizes the recent involvement of nanotechnology from the development of a biosensor to fabrication of a multifunctional nanohybrid system for respiratory and deadly viruses, along with the recent interventions and current understanding about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

TL;DR: The fast, safe, modulable and specific TCO/Tz pretargeting showed high potentiality as a theranostic tool to get more personalized and precise cancer care.

TL;DR: The outlook of EISA for developing supramolecular anticancer medicine that inhibits multiple hallmark capabilities of cancer is given.

TL;DR: A novel SERS biosensing platform combining the target-responsive DNA hydrogel for the sensitive detection of AFP and the sequence of linker strand in DNA Hydrogel can be specifically encoded into a new aptamer that responds to other cancer markers.

TL;DR: This review will provide an overview of commonly used biomaterials for forming synthetic hydrogels for tissue engineering applications and techniques for modifying them to with bioactive properties to elicit the desired cell responses.

TL;DR: HA-GC-DOX/CXB is a potential anti-cancer therapy that controlled release under acidic tumor microenvironments and enhanced CD44 overexpressed tumor target efficacy.

TL;DR: Conjugation of indocyanine green with NIR dye led to a molecular-like photothermal nanoparticle (ICG4-GS-Au25) with significantly enhanced ICG photostability and tumor targeting, offering a new pathway to meet FDA's criteria for the clinical translation of nanomedicines.

TL;DR: An in situ one-step bioorthogonal click chemistry offers improved labeling efficiency, biocompatibility and imaging sensitivy compared to standard exosomes (ST-Exo), purified with classical ultracentrifugation or carbocyanine lipophilic dye (DiD)-labeled exosome in vitro.

TL;DR: A strategy to prepare clustered Fe3O4 nanoparticles (NPs) with redox-responsiveness to tumor microenvironment to achieve switchable T2/T1-weighted dual mode MR imaging applications for dynamic precision imaging of tumors.

TL;DR: In vivo antitumor experiments manifested that the aptamer-modified SERS nanotags significantly restrained tumor growth after laser irradiation with 99% inhibition rate and good biocompatibility revealed that the SERS Nanotags could serve as a novel and precise theranostic platform for in vivo cancer diagnosis and photothermal therapy.

TL;DR: The different nanotechnology-based methods used for COV detection, i.e., optical, electrical, or PCR ones, whose sensitivity was improved by the presence of nanoparticles are summarized and vaccination methods, which comprise nanoparticles used either as adjuvants or as active principles are presented.

TL;DR: Preclinical data and first clinical results gained over the past few years by use of antibody-drug conjugates wherein the drug comprises a near-infrared photoactivatable dye delivered to tumors by a monoclonal antibody and subsequently activated to a toxic entity solely at sites of tumors are described.

TL;DR: As-prepared porphyrin-based nanoparticles are promising nanoagents for PDT/PTT in clinic and can generate heat and reactive oxygen species simultaneously induced by a single laser.

TL;DR: This review will focus on small-molecule NIRF probes used to detect β-amyloid, tau proteins and reactive oxygen species in vivo during recent four years and believes that some new directions raised herein will benefit the future development of N IRF probes in the field of AD research.

TL;DR: The focus is on the chemical aspects of PSMA, e.g., imaging label, spacer moiety, and targeting vector and their impact on in vitro and in vivo tracer characteristics (e.g, affinity, tumor uptake, and clearance pattern).

TL;DR: Conditions utilizing an N-heterocyclic carbene–palladium catalyst are developed that extends this reaction to the coupling of DNA-conjugated (hetero)aromatic chlorides with (heterO)ar automatic and select aliphatic amine nucleophiles to build a 63 million-membered DECL.

TL;DR: An overview of the available chemical strategies to achieve metal-peptidic bioconjugates for biomedical applications, focusing on the types of chemical functionalities used to tether the drug to the peptide directly or indirectly, and a number of possible future directions and applications.