C
Cleiton Martins Souza
Researcher at University of Geneva
Publications - 11
Citations - 760
Cleiton Martins Souza is an academic researcher from University of Geneva. The author has contributed to research in topics: Protein tyrosine phosphatase & Phosphorylation. The author has an hindex of 9, co-authored 11 publications receiving 670 citations. Previous affiliations of Cleiton Martins Souza include McGill University.
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Journal ArticleDOI
Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane.
Yvonne M. te Welscher,Hendrik H. ten Napel,Miriam Masià Balagué,Cleiton Martins Souza,Howard Riezman,Ben de Kruijff,Eefjan Breukink +6 more
TL;DR: It is demonstrated that natamycin acts via a novel mode of action and blocks fungal growth by binding specifically to ergosterol in model membranes.
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Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology
Xue Li Guan,Cleiton Martins Souza,Harald Pichler,Gisele Dewhurst,Olivier Schaad,Kentaro Kajiwara,Hirotomo Wakabayashi,Tanya Ivanova,Guillaume A. Castillon,Manuele Piccolis,Fumiyoshi Abe,Robbie Loewith,Kouichi Funato,Markus R. Wenk,Howard Riezman +14 more
TL;DR: Using lipid analysis by mass spectrometry and a genetic approach on mutants in sterol metabolism, it is shown that cells adjust their membrane composition in response to mutant sterol structures preferentially by changing their sphingolipid composition.
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PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders.
TL;DR: Interestingly, mutations in a PTP‐PEST‐ and PTP-HSCF‐interacting protein, PSTPIP1, were identified in humans with pyogenic sterile arthritis, pyoderma gangrenosum, and acne and familial recurrent arthritis, two autoinflammatory diseases, suggesting that these two PTPs may be negative regulators of inflammation.
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A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance
Cleiton Martins Souza,Tatjana M. E. Schwabe,Harald Pichler,Birgit Ploier,Erich Leitner,Xue Li Guan,Markus R. Wenk,Isabelle Riezman,Howard Riezman +8 more
TL;DR: It is shown that solute transporters for tryptophan and arginine are functional, whereas the export of weak organic acids via Pdr12p, a multi-drug resistance family member, is not, which reveals a sterol function that is probably dependent upon a precise sterol structure.
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The Phosphatase PTP-PEST/PTPN12 Regulates Endothelial Cell Migration and Adhesion, but Not Permeability, and Controls Vascular Development and Embryonic Viability
Cleiton Martins Souza,Dominique Davidson,Inmoo Rhee,Jean-Philippe Gratton,Elaine C. Davis,André Veillette,André Veillette +6 more
TL;DR: PTP-PEST is a key regulator of integrin-mediated functions in endothelial cells seemingly through its capacity to control Cas, paxillin, and Pyk2, which explains at least in part the essential role of PTP- PEST in embryonic development and viability.